SAAG-4 is a novel mosquito salivary protein that programmes host CD4 T cells to express IL-4.
SAAG-4 is a novel mosquito salivary protein that programmes host CD4 T cells to express IL-4.
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DOI：
10.1111/j.1365-3024.2009.01096.x
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发表时间：
2009-06
影响因子：
2.2
通讯作者：
Wikel SK
中科院分区：
文献类型：
--
作者：
Boppana VD;Thangamani S;Adler AJ;Wikel SK
Mosquitoes represent the most important vector for transmitting pathogens that cause human disease. Central to pathogen transmission is the ability to divert the host immune system away from Th1 and towards Th2 responsiveness. Identification of the mosquito factor(s) critical for programming Th2 responsiveness should therefore lead to strategies to neutralize their function and thus prevent disease transmission. In the current study, we used a TCR transgenic adoptive transfer system to screen gene products present in the saliva of the mosquito Aedes aegypti for their ability to program CD4 T cells to express the signature Th2 cytokine IL-4. The clone SAAG-4 encodes a secreted protein with a predicted size of 20 kDa whose function has previously been uncharacterized. Notably, SAAG-4 reduced host CD4 T cell expression of the signature Th1 cytokine IFN-γ while simultaneously increasing expression of IL-4. SAAG-4 is therefore the first identified mosquito factor that can program Th2 effector CD4 T cell differentiation.
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影响因子：
4.4
作者：
Higgins, AD;Mihalyo, MA;Adler, AJ
通讯作者：
Adler, AJ
DOI：
10.1073/pnas.91.1.138
发表时间：
1994-01-04
影响因子：
11.1
作者：
CHAMPAGNE, DE;RIBEIRO, JMC
通讯作者：
RIBEIRO, JMC
DOI：
10.1016/0305-0491(84)90081-6
发表时间：
1984-01-01
影响因子：
2.2
作者：
RIBEIRO, JMC;SARKIS, JJF;SPIELMAN, A
通讯作者：
SPIELMAN, A
用II类主要的组织相容性复合受体的CD8+单个阳性细胞的胸腺选择。
影响因子：
15.3
作者：
Kirberg, Joerg;Baron, Agnes;Jakob, Sylvia;Rolink, Antonius;Karjalainen, Klaus;Von Boehmer, Harald
通讯作者：
Von Boehmer, Harald
影响因子：
2.1
作者：
Edwards, JF;Higgs, S;Beaty, BJ
通讯作者：
Beaty, BJ