Metabolic engineering for production of biorenewable fuels and chemicals: contributions of synthetic biology.
Metabolic engineering for production of biorenewable fuels and chemicals: contributions of synthetic biology.
复制标题
DOI：
10.1155/2010/761042
复制
发表时间：
2010
影响因子：
--
通讯作者：
Ingram LO
中科院分区：
文献类型：
--
作者：
Jarboe LR;Zhang X;Wang X;Moore JC;Shanmugam KT;Ingram LO
通过植物材料的微生物发酵生产燃料和化学品是石化生产的理想替代方案。生物可再生燃料和化学品的发酵生产需要生物催化剂的工程设计，能够快速有效地将糖转化为目标产品，其成本与现有的石化工艺相比具有竞争力。同样重要的是，生物催化剂对极端发酵条件、生物质衍生的抑制剂及其目标产物具有鲁棒性。传统代谢工程在这一领域取得了巨大进步，但合成生物学已经并将继续为这一领域做出贡献，特别是在下一代生物燃料方面。这项工作回顾了代谢工程和合成生物学在生物可再生燃料和化学品生产的生物催化剂工程中的应用，例如乙醇、丁醇、乙酸盐、乳酸盐、琥珀酸盐、丙氨酸和木糖醇。我们还研究了该领域现有的挑战，并讨论了提高生物催化剂对化学抑制剂的耐受性的策略。
Production of fuels and chemicals through microbial fermentation of plant material is a desirable alternative to petrochemical-based production. Fermentative production of biorenewable fuels and chemicals requires the engineering of biocatalysts that can quickly and efficiently convert sugars to target products at a cost that is competitive with existing petrochemical-based processes. It is also important that biocatalysts be robust to extreme fermentation conditions, biomass-derived inhibitors, and their target products. Traditional metabolic engineering has made great advances in this area, but synthetic biology has contributed and will continue to contribute to this field, particularly with next-generation biofuels. This work reviews the use of metabolic engineering and synthetic biology in biocatalyst engineering for biorenewable fuels and chemicals production, such as ethanol, butanol, acetate, lactate, succinate, alanine, and xylitol. We also examine the existing challenges in this area and discuss strategies for improving biocatalyst tolerance to chemical inhibitors.
登录
查看更多内容
影响因子：
9.9
作者：
Andersen, Mikael Rordam;Nielsen, Michael Lynge;Nielsen, Jens
通讯作者：
Nielsen, Jens
影响因子：
9.9
作者：
Brynildsen, Mark P.;Liao, James C.
通讯作者：
Liao, James C.
影响因子：
2.1
作者：
Bauer, Andreas Peter;Dieckmann, Sarah Maria;Schleifer, Karl-Heinz
通讯作者：
Schleifer, Karl-Heinz
DOI：
10.1073/pnas.0337684100
发表时间：
2003-02-04
影响因子：
11.1
作者：
Causey, TB;Zhou, S;Ingram, LO
通讯作者：
Ingram, LO
影响因子：
2.7
作者：
Berraud, C
通讯作者：
Berraud, C