The Genomic Impact of Selection for Virulence against Resistance in the Potato Cyst Nematode, Globodera pallida.
The Genomic Impact of Selection for Virulence against Resistance in the Potato Cyst Nematode, Globodera pallida.
复制标题
马铃薯胞囊线虫（Globodera pallida）抗性毒力选择的基因组影响。
DOI：
10.3390/genes11121429
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发表时间：
2020-11-28
期刊：
影响因子：
3.5
通讯作者：
Blok VC
中科院分区：
文献类型：
--
作者：
Varypatakis K;Véronneau PY;Thorpe P;Cock PJA;Lim JT;Armstrong MR;Janakowski S;Sobczak M;Hein I;Mimee B;Jones JT;Blok VC
虽然利用自然抗性是对抗马铃薯胞囊线虫（PCN）Globodera pallida的最有效的管理方法，但具有不同毒力特征的致病型的存在构成了实现这一目标的限制。GpaV（来自Solanum vernei）和H3（来自S.马铃薯andigena CPC 2802（来自英联邦马铃薯保藏中心）广泛用于欧洲马铃薯产业的马铃薯育种计划。然而，抗性品种的使用可能会推动对毒力的强烈选择，这使得种群中毒力等位基因的频率增加，从而出现高毒力线虫谱系。本研究的目的是鉴定G. pallida种群对上述抗性来源的毒力选择，以及选择过程对线虫基因组的影响。种群中的选择驱动被认为是特定于其遗传背景的。在基因组水平，发现11个基因代表候选Avr基因。大多数决定选择的变异呼叫与H3选择的群体相关，而其中许多似乎组织在基因组岛中，促进选择进化。这些表型和基因组的研究结果结合组织学研究揭示了潜在的机制选择G。苍白球。
Although the use of natural resistance is the most effective management approach against the potato cyst nematode (PCN) Globodera pallida, the existence of pathotypes with different virulence characteristics constitutes a constraint towards this goal. Two resistance sources, GpaV (from Solanum vernei) and H3 from S. tuberosum ssp. andigena CPC2802 (from the Commonwealth Potato Collection) are widely used in potato breeding programmes in European potato industry. However, the use of resistant cultivars may drive strong selection towards virulence, which allows the increase in frequency of virulent alleles in the population and therefore, the emergence of highly virulent nematode lineages. This study aimed to identify Avirulence (Avr) genes in G. pallida populations selected for virulence on the above resistance sources, and the genomic impact of selection processes on the nematode. The selection drive in the populations was found to be specific to their genetic background. At the genomic level, 11 genes were found that represent candidate Avr genes. Most of the variant calls determining selection were associated with H3-selected populations, while many of them seem to be organised in genomic islands facilitating selection evolution. These phenotypic and genomic findings combined with histological studies performed revealed potential mechanisms underlying selection in G. pallida.
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影响因子：
12.3
作者：
Eves-van den Akker S;Laetsch DR;Thorpe P;Lilley CJ;Danchin EG;Da Rocha M;Rancurel C;Holroyd NE;Cotton JA;Szitenberg A;Grenier E;Montarry J;Mimee B;Duceppe MO;Boyes I;Marvin JM;Jones LM;Yusup HB;Lafond-Lapalme J;Esquibet M;Sabeh M;Rott M;Overmars H;Finkers-Tomczak A;Smant G;Koutsovoulos G;Blok V;Mantelin S;Cock PJ;Phillips W;Henrissat B;Urwin PE;Blaxter M;Jones JT
通讯作者：
Jones JT
DOI：
10.1126/science.1236011
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dangl JL;Horvath DM;Staskawicz BJ
通讯作者：
Staskawicz BJ
影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.
影响因子：
4.9
作者：
Carpentier, Jean;Esquibet, Magali;Grenier, Eric
通讯作者：
Grenier, Eric
影响因子：
5.4
作者：
Bakker, Erin;Borm, Theo;Prins, Pjotr;van der Vossen, Edwin;Uenk, Gerda;Arens, Marjon;de Boer, Jan;van Eck, Herman;Muskens, Marielle;Vossen, Jack;van der Linden, Gerard;van Ham, Roeland;Klein-Lankhorst, Rene;Visser, Richard;Smant, Geert;Bakker, Jaap;Goverse, Aska
通讯作者：
Goverse, Aska