Children's Brain Development Benefits from Longer Gestation.
Children's Brain Development Benefits from Longer Gestation.
复制标题
DOI：
10.3389/fpsyg.2011.00001
复制
发表时间：
2011
影响因子：
3.8
通讯作者：
Sandman CA
中科院分区：
文献类型：
--
作者：
Davis EP;Buss C;Muftuler LT;Head K;Hasso A;Wing DA;Hobel C;Sandman CA
与妊娠缩短相关的大脑发育中断会使个人在整个一生中面临发展为行为和心理障碍的风险。本研究的目的是确定在新生儿病程稳定的健康儿童中，延长孕期对大脑发育的益处是否存在于整个孕周范围内。用结构磁共振成像对100名出生于28至41周、新生儿病程稳定的健康右利手6至10岁儿童的神经发育进行了评估。数据表明，较长的妊娠期有利于神经发育。妊娠持续时间较长与灰质密度的区域特异性增加有关。此外，即使只考虑足月出生的孩子，较长的孕期对大脑发育的好处也是存在的。这些发现表明，即使是轻微的孕期缩短，也会对足月儿和早产儿的神经发育产生深远而持久的影响，并可能导致健康和疾病的长期风险。
Disruptions to brain development associated with shortened gestation place individuals at risk for the development of behavioral and psychological dysfunction throughout the lifespan. The purpose of the present study was to determine if the benefit for brain development conferred by increased gestational length exists on a continuum across the gestational age spectrum among healthy children with a stable neonatal course. Neurodevelopment was evaluated with structural magnetic resonance imaging in 100 healthy right-handed 6- to 10-year-old children born between 28 and 41 gestational weeks with a stable neonatal course. Data indicate that a longer gestational period confers an advantage for neurodevelopment. Longer duration of gestation was associated with region-specific increases in gray matter density. Further, the benefit of longer gestation for brain development was present even when only children born full term were considered. These findings demonstrate that even modest decreases in the duration of gestation can exert profound and lasting effects on neurodevelopment for both term and preterm infants and may contribute to long-term risk for health and disease.
登录
查看更多内容
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
11.2
作者：
Hüppi, PS;Warfield, S;Volpe, JJ
通讯作者：
Volpe, JJ
影响因子：
8
作者：
Delobel-Ayoub, Malika;Arnaud, Catherine;Larroque, Beatrice
通讯作者：
Larroque, Beatrice
影响因子：
10.6
作者：
Bergman, Kristin;Sarkar, Pampa;Glover, Vivette;O'Connor, Thomas G.
通讯作者：
O'Connor, Thomas G.
DOI：
10.1016/j.jaac.2010.02.002
发表时间：
2010-05-01
影响因子：
13.3
作者：
Johnson, Samantha;Hollis, Chris;Marlow, Neil
通讯作者：
Marlow, Neil