Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment.
Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment.
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DOI：
10.1016/j.biopsych.2010.01.002
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发表时间：
2010-06-01
影响因子：
10.6
通讯作者：
O'Connor, Thomas G.
中科院分区：
文献类型：
--
作者：
Bergman, Kristin;Sarkar, Pampa;Glover, Vivette;O'Connor, Thomas G.
实验动物研究表明，早期糖皮质激素暴露可能对后代的神经发育产生持久的影响;动物研究还表明，这种影响可能会被积极的产后养育所消除。这些发现与人类的相关性尚不清楚。我们前瞻性地跟踪了125位母亲和她们正常发育的孩子，从怀孕到产后17个月。平均在妊娠17.2周时获得羊水;婴儿在平均17个月时使用贝利婴儿发育量表进行评估，并根据标准的安斯沃思陌生情境评估进行婴儿-母亲依恋分类评级。产前皮质醇暴露，指数羊水水平，负预测婴儿的认知能力，独立于产前，产科和社会经济因素。这种关联受到母子依恋的调节：在不安全依恋的儿童中，相关性为（r（54）=-0.47，p <.001）;相反，在安全依恋的儿童中，这种关联不存在（r（70）=-0.05，ns）。这些发现模拟了实验动物的发现，并提供了第一个直接的人类证据，证明子宫内皮质醇增加与认知发育受损有关，其影响取决于母婴关系的质量。
Experimental animal studies suggest that early glucocorticoid exposure may have lasting effects on the neurodevelopment of the offspring; animal studies also suggest that this effect may be eliminated by positive postnatal rearing. The relevance of these findings to humans is not known. We prospectively followed 125 mothers and their normally developing children from pregnancy through 17 months postnatal. Amniotic fluid was obtained at, on average, 17.2 weeks gestation; infants were assessed at an average age of 17 months with the Bayley Scales of Infant Development and ratings of infant-mother attachment classification were made from the standard Ainsworth Strange Situation assessment. Prenatal cortisol exposure, indexed by amniotic fluid levels, negatively predicted cognitive ability in the infant, independent of prenatal, obstetric, and socioeconomic factors. This association was moderated by child–mother attachment: in children with an insecure attachment the correlation was (r(54) = −.47, p <.001); in contrast, the association was nonexistent in children who had a secure attachment (r(70) = −.05, ns). These findings mimic experimental animal findings and provide the first direct human evidence that increased cortisol in utero is associated with impaired cognitive development, and that its impact is dependent on the quality of the mother-infant relationship.
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影响因子：
4.6
作者：
BELSKY, J;ROVINE, M;TAYLOR, DG
通讯作者：
TAYLOR, DG
DOI：
10.1111/j.1469-7610.2008.01987.x
发表时间：
2008-10-01
影响因子：
7.6
作者：
Bergman, K.;Sarkar, P.;O'Connor, T. G.
通讯作者：
O'Connor, T. G.
DOI：
10.1111/1469-7610.00166
发表时间：
2003-09-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
Huizink, AC;de Medina, PGR;Buitelaar, JK
通讯作者：
Buitelaar, JK
影响因子：
4.2
作者：
Buitelaar, JK;Huizink, AC;Visser, GHA
通讯作者：
Visser, GHA
DOI：
10.1097/chi.0b013e31814a62f6
发表时间：
2007-11-01
影响因子：
13.3
作者：
Bergman, Kristin;Sarkar, Pampa;Glover, Vivette
通讯作者：
Glover, Vivette