The Seroprevalence of Dengue Virus Infection and Its Association With Iron (Fe) Level in Pregnant Women in Guangzhou, China.
The Seroprevalence of Dengue Virus Infection and Its Association With Iron (Fe) Level in Pregnant Women in Guangzhou, China.
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中国广州孕妇登革热病毒感染血清阳性率及其与铁 (Fe) 水平的关系
DOI：
10.3389/fmed.2021.759728
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发表时间：
2021
影响因子：
3.9
通讯作者：
Liu T
中科院分区：
文献类型：
--
作者：
Wang J;Sun J;Sun L;Ye Y;Chen H;Xiao J;He G;Hu J;Chen G;Zhou H;Dong X;Ma W;Zhang B;Liu T
登革热被认为是人类最普遍的蚊媒病毒性疾病。然而，登革病毒（DENV）在孕妇中的感染情况及其影响因素尚不清楚。在这项研究中，我们从2016年以来在中国广州进行的产前环境和后代健康（PEOH）出生队列中提取了2，076名孕妇的信息。在住院分娩期间收集受试者的外周血和清洁中段尿样本。采用间接酶联免疫吸附试验（ELISA）检测血清中登革病毒IgG抗体，电感耦合等离子体质谱法（ICP-MS）检测尿液中铁浓度，用尿肌酐校正后进行自然对数（ln-Fe）转换。登革病毒IgG抗体阳性率为2.22%（46/2,076）。年龄≥35岁（2.9%）、文化程度≤ 12年（2.5%）、人均年收入<10万元（2.4%）、不使用空调（2.4%）、不使用蚊香（2.3%）、孕期不锻炼（4.1%）的孕妇IgG抗体阳性率较高。In-Fe浓度与IgG抗体阳性风险呈U型关系。与In-Fe浓度为2.0-2.9 μg/g肌酐的妇女相比，In-Fe浓度≤2.0 μg/g肌酐的妇女IgG抗体阳性的风险略高（RR = 4.16，95% CI：0.78，19.91），3.0-3.9（RR = 1.93，95%CI：0.65，7.08）、4.0-4.9（RR = 2.19，95%CI：0.65，8.51）和≥5.0 μg/g肌酐（RR = 2.42，95%CI：0.46，11.33）。我们的研究结果表明，在中国广州的孕妇登革热IgG抗体的血清阳性率与一般人群相当。登革病毒感染的风险可能与母亲的人口统计学特征和行为有关。母亲体内铁浓度低和高可能与登革病毒感染的风险呈正相关。
Dengue fever is regarded as the most prevalent mosquito-borne viral disease in humans. However, information of dengue virus (DENV) infection in pregnant women and the influence factors remain unclear. In this study, we extracted information of 2,076 pregnant women from the Prenatal Environment and Offspring Health (PEOH) birth cohort conducted since 2016 in Guangzhou, China. Peripheral blood and clean midstream urine samples of participants were collected during their hospitalization for childbirth. Indirect enzyme-linked immunosorbent assay (ELISA) was used to detect immunoglobulin G (IgG) antibodies of DENV in serum samples, and inductively coupled plasma mass spectrometry (ICP-MS) was applied to determine the Fe concentrations in the urine samples, which were then adjusted for by urine creatinine and transformed by natural logarithm (ln-Fe). The seroprevalence of DENV IgG antibody in all included participants was 2.22% (46/2,076). We observed higher seroprevalence of IgG antibody in women aged ≥35 years (2.9%), education ≤ 12 years (2.5%), yearly income per capita <100,000 yuan (2.4%), no use of air-conditioner (2.4%), no use of mosquito coils (2.3%), and no exercise during pregnancy (4.1%). A U-shaped relationship was found between ln-Fe concentration and the risk of positive IgG antibody. Compared with women with ln-Fe concentration of 2.0–2.9 μg/g creatinine, slightly higher risks of positive IgG antibody were found among women with ≤2.0 (RR = 4.16, 95% CI: 0.78, 19.91), 3.0–3.9 (RR = 1.93, 95% CI: 0.65, 7.08), 4.0–4.9 (RR = 2.19, 95% CI: 0.65, 8.51), and ≥5.0 μg/g creatinine of ln-Fe (RR = 2.42, 95% CI: 0.46, 11.33). Our findings suggested that the seroprevalence of dengue IgG antibody in pregnant women was comparable to the general population in Guangzhou, China. The risk of DENV infection may be associated with maternal demographic characteristics and behaviors. Both maternal low and high Fe concentrations may be positively associated with the risk of DENV infection.
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影响因子：
0.6
作者：
Jain, Jenisha;Lakshmi, V;Shanmughsundaram, R.
通讯作者：
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影响因子：
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