Altered White Matter Integrity in Smokers Is Associated with Smoking Cessation Outcomes.
Altered White Matter Integrity in Smokers Is Associated with Smoking Cessation Outcomes.
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DOI：
10.3389/fnhum.2017.00438
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发表时间：
2017
影响因子：
2.9
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Huang P;Shen Z;Wang C;Qian W;Zhang H;Yang Y;Zhang M
吸烟是全世界可预防的死亡的一个重要原因。了解尼古丁成瘾和戒烟的神经机制可能为制定治疗策略提供有效的靶点。在目前的研究中，我们探索了吸烟者是否有白质改变，以及这些改变是否与戒烟结果和吸烟行为有关。66名吸烟者和37名健康的非吸烟者参加了研究。参与者接受了磁共振成像扫描和与吸烟相关的行为评估。在使用varenicline治疗12周后，28名吸烟者成功戒烟，38人戒烟失败。比较不吸烟者、未来戒烟者和复吸者的弥散参数图，以确定白质的差异。我们发现，未来的复吸者在眼眶前额区的分数各向异性(FA)显著低于不吸烟者，而在小脑的FA高于不吸烟者和未来戒烟者。与非吸烟者和未来复吸者相比，未来戒烟者中央后回FA显著降低。与非吸烟者相比，联合吸烟者双侧眶前回和左侧额上回FA较低。此外，回归分析显示左眶前额叶FA与吸烟相关行为相关。这些结果表明，吸烟者脑白质的改变可能有助于形成支撑吸烟行为的异常脑回路，并与未来的戒烟结果相关。
Smoking is a significant cause of preventable mortality worldwide. Understanding the neural mechanisms of nicotine addiction and smoking cessation may provide effective targets for developing treatment strategies. In the present study, we explored whether smokers have white matter alterations and whether these alterations are related to cessation outcomes and smoking behaviors. Sixty-six smokers and thirty-seven healthy non-smokers were enrolled. The participants underwent magnetic resonance imaging scans and smoking-related behavioral assessments. After a 12-week treatment with varenicline, 28 smokers succeeded in quitting smoking and 38 failed. Diffusion parameter maps were compared among the non-smokers, future quitters, and relapsers to identify white matter differences. We found that the future relapsers had significantly lower fractional anisotropy (FA) in the orbitofrontal area than non-smokers, and higher FA in the cerebellum than non-smokers and future quitters. The future quitters had significantly lower FA in the postcentral gyrus compared to non-smokers and future relapsers. Compared to non-smokers, pooled smokers had lower FA in bilateral orbitofrontal gyrus and left superior frontal gyrus. In addition, regression analysis showed that the left orbitofrontal FA was correlated with smoking-relevant behaviors. These results suggest that white matter alterations in smokers may contribute to the formation of aberrant brain circuits underlying smoking behaviors and are associated with future smoking cessation outcomes.
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影响因子：
3.7
作者：
Franklin TR;Wetherill RR;Jagannathan K;Johnson B;Mumma J;Hager N;Rao H;Childress AR
通讯作者：
Childress AR
影响因子：
3.7
作者：
Wylie KP;Tanabe J;Martin LF;Wongngamnit N;Tregellas JR
通讯作者：
Tregellas JR
影响因子：
--
作者：
Franklin, Teresa;Wang, Ze;Suh, Jesse J.;Hazan, Rebecca;Cruz, Jeffrey;Li, Yin;Goldman, Marina;Detre, John A.;O'Brien, Charles P.;Childress, Anna Rose
通讯作者：
Childress, Anna Rose
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Barbey AK;Koenigs M;Grafman J
通讯作者：
Grafman J
影响因子：
7.6
作者：
Kosten, TR;Scanley, BE;Wexler, BE
通讯作者：
Wexler, BE