The effects of chronic cigarette smoking on gray matter volume: influence of sex.
The effects of chronic cigarette smoking on gray matter volume: influence of sex.
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DOI：
10.1371/journal.pone.0104102
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Childress AR
中科院分区：
文献类型：
--
作者：
Franklin TR;Wetherill RR;Jagannathan K;Johnson B;Mumma J;Hager N;Rao H;Childress AR
香烟烟雾含有尼古丁和有毒化学物质，可能会导致显着的神经化学和大脑解剖学变化。基于体素的形态计量学研究通过比较尼古丁依赖个体 (ND) 和不吸烟个体的灰质体积 (GMV) 来研究吸烟对大脑的影响，但结果不一致。尽管尼古丁依赖的神经和行为特征存在性别差异，但区域 GMV 的性别差异仍然未知。目前的研究使用基于体素的形态测量法检查了 80 名 ND（41 名男性）和 80 名健康对照（41 名男性）的大样本中 GMV 的性别差异。在 ND 中，我们探讨了 GMV 是否与香烟使用和尼古丁依赖的测量值相关。所有参与者均获得了高分辨率 T1 结构扫描。使用优化的 DARTEL 方法在 SPM8 中进行分割和配准。协变量包括年龄和全球总 GMV 的估计。 p≤0.001 时差异被认为是显着的，全脑 FWE 校正的聚类概率为 p<0.025。与对照组相比，ND 中丘脑和双侧小脑中观察到的 GMV 较小，而双侧壳核和右侧海马旁回中观察到的 GMV 较高。与对照组相比，女性和男性 ND 中丘脑 GMV 均较低。女性 ND 的左侧小脑、腹内侧和眶额皮质的 GMV 也较低，但没有出现 GMV 较高的区域。男性ND的双侧小脑GMV较低，双侧海马旁和左壳核GMV较高。在雄性 ND 中，左侧壳核的 GMV 与包年数相关。这项研究是在一个大型队列中进行的，有助于我们了解尼古丁成瘾的大脑形态，并提供性别特异性对 ND 中 GMV 影响的额外证据。识别与性别有关的大脑脆弱性为个性化治疗提供了方法框架，以提高两性的复发率。
Cigarette smoke contains nicotine and toxic chemicals and may cause significant neurochemical and anatomical brain changes. Voxel-based morphometry studies have examined the effects of smoking on the brain by comparing gray matter volume (GMV) in nicotine dependent individuals (NDs) to nonsmoking individuals with inconsistent results. Although sex differences in neural and behavioral features of nicotine dependence are reported, sex differences in regional GMV remain unknown. The current study examined sex differences in GMV in a large sample of 80 NDs (41 males) and 80 healthy controls (41 males) using voxel-based morphometry. Within NDs, we explored whether GMV was correlated with measures of cigarette use and nicotine dependence. High-resolution T1 structural scans were obtained from all participants. Segmentation and registration were performed in SPM8 using the optimized DARTEL approach. Covariates included age and an estimate of total global GMV. Differences were considered significant at p≤0.001, with a whole brain FWE-corrected cluster probability of p<0.025. Among NDs compared to Controls less GMV was observed in the thalamus and bilateral cerebellum and greater GMV was observed in the bilateral putamen and right parahippocampus. Lower thalamic GMV was observed in both female and male NDs compared to Controls. Female NDs also had lower GMV in the left cerebellum and in the ventral medial and orbitofrontal cortices with no areas of greater GMV. Male NDs had lower GMV in bilateral cerebellum and greater GMV in bilateral parahippocampus and left putamen. Within male NDs, GMV in the left putamen was correlated with number of pack years. This study, conducted in a large cohort, contributes to our knowledge of brain morphology in nicotine addiction and provides additional evidence of sex-specific effects on GMV in NDs. Identifying brain vulnerabilities with respect to sex provides a methodological framework for personalized therapies to improve relapse rates for both sexes.
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作者：
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通讯作者：
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