Nicotine increases cerebellar activity during finger tapping.

Nicotine increases cerebellar activity during finger tapping.
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DOI:
10.1371/journal.pone.0084581
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发表时间:
2013
期刊:
影响因子:
3.7
通讯作者:
Tregellas JR
Tregellas JR
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Wylie KP;Tanabe J;Martin LF;Wongngamnit N;Tregellas JR

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Nicotine improves performance on several cognitive and sensorimotor tasks. The neuronal mechanisms associated with these changes in performance are, however, largely unknown. Functional magnetic resonance imaging (fMRI) was used to examine the effect of nicotine on neuronal response in nineteen healthy subjects while they performed an auditory-paced finger tapping task. Subjects performed the task, after receiving either a nicotine patch or placebo treatment, in a single blind, crossover design. Compared to placebo, nicotine treatment increased response in the cerebellar vermis. Increased vermal activity, in the absence of changes in other task-related regions suggests specificity in nicotine’s effects.
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