The role of radionuclide probes for monitoring anti-tumor drugs efficacy: A brief review.
The role of radionuclide probes for monitoring anti-tumor drugs efficacy: A brief review.
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DOI：
10.1016/j.biopha.2017.08.079
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
de Barros ALB
中科院分区：
文献类型：
--
作者：
Fernandes RS;de Aguiar Ferreira C;Soares DCF;Maffione AM;Townsend DM;Rubello D;de Barros ALB
尽管最近在新治疗药物和诊断成像方式的开发方面取得了进展，但癌症仍然是全球死亡的主要原因之一。对癌症分子特征的更好理解促进了新一代抗癌药物和诊断剂的开发，这些药物和诊断剂特异性靶向分子组分，如基因、配体、受体和信号传导通路。然而，肿瘤的内在异质性阻碍了靶向治疗的总体成功，即使在具有相似肿瘤类型但对治疗的不可预测的不同反应的患者中也是如此。从这个意义上说，治疗后反应监测变得不可或缺，核医学成像方式可以提供早期指示治疗效果的工具。在此，我们简要讨论了PET和SPECT成像在监测癌症治疗中的作用，以及目前正在研究的肿瘤治疗反应评估的放射性标记探针的更新。
Despite recent advances in the development of new therapeutic agents and diagnostic imaging modalities, cancer is still one of the main causes of death worldwide. A better understanding of the molecular signature of cancer has promoted the development of a new generation of anti-cancer drugs and diagnostic agents that specifically target molecular components such as genes, ligands, receptors and signaling pathways. However, intrinsic heterogeneity of tumors has hampered the overall success of target therapies even among patients with similar tumor types but unpredictable different responses to therapy. In this sense, post-treatment response monitoring becomes indispensable and nuclear medicine imaging modalities could provide the tools for an early indication of therapeutic efficacy. Herein, we briefly discuss the current role of PET and SPECT imaging in monitoring cancer therapy together with an update on the current radiolabeled probes that are currently investigated for tumor therapy response assessment.
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影响因子：
--
作者：
Niccoli Asabella A;Cascini GL;Altini C;Paparella D;Notaristefano A;Rubini G
通讯作者：
Rubini G
影响因子：
4.9
作者：
Beaino W;Nedrow JR;Anderson CJ
通讯作者：
Anderson CJ
影响因子：
0.9
作者：
Artiko, Vera;Afgan, Aida;Obradovic, Vladimir
通讯作者：
Obradovic, Vladimir
影响因子：
2.8
作者：
Aung W;Tsuji AB;Sudo H;Sugyo A;Furukawa T;Ukai Y;Kurosawa Y;Saga T
通讯作者：
Saga T
DOI：
10.1007/s00259-017-3728-y
发表时间：
2017-08-01
影响因子：
9.1
作者：
Bozkurt, Murat Fani;Virgolini, Irene;Fanti, Stefano
通讯作者：
Fanti, Stefano