Brain lesions affecting gait recovery in stroke patients.
Brain lesions affecting gait recovery in stroke patients.
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DOI：
10.1002/brb3.868
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发表时间：
2017-11
影响因子：
3.1
通讯作者：
Lim SH
中科院分区：
文献类型：
--
作者：
Lee KB;Kim JS;Hong BY;Sul B;Song S;Sung WJ;Hwang BY;Lim SH
步态恢复是中风患者的一个重要目标。一些研究试图揭示特定脑部损伤和步态恢复之间的关系，但特定脑部损伤对步态的影响尚不清楚。因此，我们调查了中风损伤对中风患者步态恢复的影响。总共有30名中风患者在一项逆行的纵向观察研究中被评估。为了评估步态功能，对功能性步行类别(FAC)进行了四次测试：最初(在2周内)以及中风开始后1、3和6个月。通过重叠、减影和基于体素的病变症状图(VLSM)分析脑病变。随着时间的推移，FAC步行能力明显提高。减影分析显示，发病后6个月内，累及放射冠、内囊、苍白球和壳核与步态恢复不良有关。在发病6个月后，尾状核确实影响步态恢复不良。VLSM显示，发病3个月时，放射冠、内囊、苍白球、壳核和扣带与步态恢复不良有关。放射冠、内囊、苍白球、壳核、初级运动皮质、尾状核与发病6个月后步态恢复差有关。结果确定了中风患者步态恢复的几个重要脑部病变。这些结果可能有助于制定步态康复策略和了解卒中患者步态的预后。
Gait recovery is an important goal in stroke patients. Several studies have sought to uncover relationships between specific brain lesions and the recovery of gait, but the effects of specific brain lesions on gait remain unclear. Thus, we investigated the effects of stroke lesions on gait recovery in stroke patients. In total, 30 subjects with stroke were assessed in a retrograde longitudinal observational study. To assess gait function, the functional ambulation category (FAC) was tested four times: initially (within 2 weeks) and 1, 3, and 6 months after the onset of the stroke. Brain lesions were analyzed via overlap, subtraction, and voxel‐based lesion symptom mapping (VLSM). Ambulation with FAC improved significantly with time. Subtraction analysis showed that involvement of the corona radiata, internal capsule, globus pallidus, and putamen were associated with poor recovery of gait throughout 6 months after onset. The caudate nucleus did influence poor recovery of gait at 6 months after onset. VLSM revealed that corona radiata, internal capsule, globus pallidus, putamen and cingulum were related with poor recovery of gait at 3 months after onset. Corona radiata, internal capsule, globus pallidus, putamen, primary motor cortex, and caudate nucleus were related with poor recovery of gait at 6 months after onset. Results identified several important brain lesions for gait recovery in patients with stroke. These results may be useful for planning rehabilitation strategies for gait and understanding the prognosis of gait in stroke patients.
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影响因子：
4.3
作者：
Chen, CL;Tang, FT;Wong, MK
通讯作者：
Wong, MK
影响因子：
2.4
作者：
Lee KP;Kim JE;Park WH
通讯作者：
Park WH
影响因子：
2.2
作者：
Hoyer, Ellen;Jahnsen, Reidun;Strand, Liv Inger
通讯作者：
Strand, Liv Inger
DOI：
10.1016/j.clinph.2013.10.008
发表时间：
2014-05
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Peterson DS;Pickett KA;Duncan RP;Perlmutter JS;Earhart GM
通讯作者：
Earhart GM
影响因子：
4.8
作者：
Jones PS;Pomeroy VM;Wang J;Schlaug G;Tulasi Marrapu S;Geva S;Rowe PJ;Chandler E;Kerr A;Baron JC;SWIFT-Cast investigators
通讯作者：
SWIFT-Cast investigators