Brain activity during complex imagined gait tasks in Parkinson disease.
Brain activity during complex imagined gait tasks in Parkinson disease.
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DOI：
10.1016/j.clinph.2013.10.008
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Earhart GM
中科院分区：
文献类型：
--
作者：
Peterson DS;Pickett KA;Duncan RP;Perlmutter JS;Earhart GM
功能性磁共振成像（fMRI）期间的运动想象可以评估在扫描仪中无法完成的任务（如行走）期间的大脑活动。我们使用步态成像来评估帕金森病（PD）运动的神经病理生理学。在简单（向前）和复杂（向后，转向）步态成像过程中，在五个运动区域（补充运动区（SMA），苍白球（GP），壳核，中脑运动区，小脑运动区）测量脑活动。大脑活动与地上行走速度相关。在所有任务中，与对照组相比，PD在苍白球中表现出降低的活性。与向前或向后行走相比，PD患者（而非对照组）在想象转弯时SMA表现出更多的活动。在PD中，步行速度与几个区域的大脑活动相关。在想象转弯过程中PD中SMA活动的改变可能代表复杂步态中的代偿性神经适应。GP的活性降低和与运动功能的正相关性表明该区域的活性降低可能与运动功能障碍有关。这项研究阐明了帕金森病患者步态过程中神经活动的变化，强调了测试简单和复杂任务的重要性。结果支持运动区域的活动和步行能力之间的正相关关系。
Motor imagery during functional magnetic resonance imaging (fMRI) allows assessment of brain activity during tasks, like walking, that cannot be completed in a scanner. We used gait imagery to assess the neural pathophysiology of locomotion in Parkinson disease (PD). Brain activity was measured in five locomotor regions (supplementary motor area (SMA), globus pallidus (GP), putamen, mesencephalic locomotor region, cerebellar locomotor region) during simple (forward) and complex (backward, turning) gait imagery. Brain activity was correlated to overground walking velocity. Across tasks, PD exhibited reduced activity in the globus pallidus compared to controls. People with PD, but not controls, exhibited more activity in the SMA during imagined turning compared to forward or backward walking. In PD, walking speed was correlated to brain activity in several regions. Altered SMA activity in PD during imagined turning may represent compensatory neural adaptations during complex gait. The lowered activity and positive correlation to locomotor function in GP suggests reduced activity in this region may relate to locomotor dysfunction. This study elucidates changes in neural activity during gait in PD, underscoring the importance of testing simple and complex tasks. Results support a positive relationship between activity in locomotor regions and walking ability.
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