Importing genetically altered animals: ensuring quality.

Importing genetically altered animals: ensuring quality.
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DOI:
10.1007/s00335-021-09908-x
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发表时间:
2022-03
期刊:
Mammalian genome : official journal of the International Mammalian Genome Society
影响因子:
--
通讯作者:
Teboul L
Teboul L
中科院分区:
其他
文献类型:
--
作者:
Birling MC;Fray MD;Kasparek P;Kopkanova J;Massimi M;Matteoni R;Montoliu L;Nutter LMJ;Raspa M;Rozman J;Ryder EJ;Scavizzi F;Voikar V;Wells S;Pavlovic G;Teboul L

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使用实验室动物进行研究的可重复性要求对其质量进行可靠的管理,特别是其遗传学、健康和环境,所有这些都有助于其表型。这些生物材料在研究人员之间转移的时间点特别敏感,因为这可能导致动物和/或其文件的完整性丧失。在这里,我们描述了在共享啮齿动物研究模型时应确认的实验动物质量的各个方面。我们还讨论了生物材料库如何支持科学界,以确保实验动物质量的连续性。质量的概念和储存库本身的作用延伸到所有生物材料的交换和支持这些试剂共享的所有网络。
The reproducibility of research using laboratory animals requires reliable management of their quality, in particular of their genetics, health and environment, all of which contribute to their phenotypes. The point at which these biological materials are transferred between researchers is particularly sensitive, as it may result in a loss of integrity of the animals and/or their documentation. Here, we describe the various aspects of laboratory animal quality that should be confirmed when sharing rodent research models. We also discuss how repositories of biological materials support the scientific community to ensure the continuity of the quality of laboratory animals. Both the concept of quality and the role of repositories themselves extend to all exchanges of biological materials and all networks that support the sharing of these reagents.
免疫介导的疾病的微生物组和啮齿动物模型。
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影响因子: --
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