The osmotic component of ethanol and urea action is critical for their immediate stimulation of thyrotropin-releasing hormone (TRH) release from rat brain septum.
The osmotic component of ethanol and urea action is critical for their immediate stimulation of thyrotropin-releasing hormone (TRH) release from rat brain septum.
复制标题
乙醇和尿素作用的渗透成分对于立即刺激大鼠脑中隔释放促甲状腺素释放激素（TRH）至关重要。
作者：
J. Kučerová;V. S̆trbák
有相当多的证据表明饮酒与镇静作用和脑隔膜中的TRH有关。此外，先天性隔TRH浓度与乙醇偏好程度呈负相关。最近，我们在大鼠中证明，四周的乙醇饮用增加了50%的间隔TRH含量。我们之前已经证明乙醇会诱导神经元肿胀，已知这会引起各种类型细胞分泌激素、肽和氨基酸。因此，我们探讨了低渗介质和80和160 mM乙醇和80 mM尿素（均渗透分子）在等渗和高渗（防止细胞肿胀）介质上的TRH在体外释放的大鼠隔膜的效果。降低介质渗透压导致低渗相关的TRH分泌增加。乙醇和尿素刺激TRH释放仅在等渗溶液中。我们的数据表明，临床相关浓度的乙醇可以诱导TRH释放的隔膜的机制，涉及神经元肿胀。
There is considerable evidence linking alcohol consumption and sedation and TRH in the brain septum. Moreover, innate septal TRH concentration is inversely related to the degree of ethanol preference. Recently we demonstrated in rats that four-week ethanol drinking increased the septal TRH content by 50 %. We had shown previously that ethanol induces neuronal swelling, which is known to evoke the secretion of hormones, peptides and amino acids from various types of cells. We have therefore explored the effect of hyposmotic medium and of 80 and 160 mM ethanol and 80 mM urea (both permeant molecules) in isosmotic and hyperosmotic (preventing cell swelling) media on the in vitro release of TRH by the rat septum. Lowering medium osmolarity resulted in a hyposmolarity-related increase in TRH secretion. Both ethanol and urea stimulated TRH release only in isosmolar solution. Our data indicate that ethanol in clinically relevant concentrations can induce TRH release from the septum by a mechanism involving neuronal swelling.
登录
查看更多内容
通过新型 TRH 类似物 TA-0910 减弱酒精偏好大鼠的酒精偏好。
DOI：
10.1111/j.1530-0277.1992.tb01385.x
发表时间：
1992
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Rezvani,AH;Garbutt,JC;Shimoda,K;Garges,PL;Janowsky,DS;Mason,GA
通讯作者：
Mason,GA
中等低渗透压通过诱导胞质游离钙增加来刺激 GH4C1 细胞中催乳素的分泌。
影响因子：
4.8
作者：
Sato,N;Wang,XB;Greer,MA;Greer,SE;McAdams,S;Oshima,T
通讯作者：
Oshima,T
促甲状腺激素释放激素类似物 TA-0910 可抑制饮酒的非洲绿猴的酒精摄入量。
DOI：
--
发表时间：
1997
期刊：
Alcoholism, clinical and experimental research.
影响因子：
--
作者：
Rezvani,AH;Garbutt,JC;Overstreet,DH;Li,L;Walker,CH;Yang,Y;Mason,GA
通讯作者：
Mason,GA
等渗而非高渗乙醇刺激灌注大鼠正中隆起的 LHRH 分泌。
影响因子：
4.1
作者：
Inukai,T;Wang,X;Greer,MA;Greer,SE
通讯作者：
Greer,SE
乙醇在中枢神经系统中特定位点作用的证据。
DOI：
--
发表时间：
1985
期刊：
Alcohol and drug research
影响因子：
--
作者：
McCown,TJ;Frye,GD;Breese,GR
通讯作者：
Breese,GR