Sleep disturbances and depression severity in patients with Parkinson's disease.
Sleep disturbances and depression severity in patients with Parkinson's disease.
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DOI：
10.1002/brb3.967
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发表时间：
2018-06
影响因子：
3.1
通讯作者：
Bowers D
中科院分区：
文献类型：
--
作者：
Kay DB;Tanner JJ;Bowers D
帕金森病（Parkinson's disease，PD）是一种多系统运动障碍性疾病，伴有睡眠障碍和抑郁。睡眠障碍和抑郁症的严重程度有双向关联。这种关联可能在更容易受到睡眠障碍和抑郁严重程度的有害后果的个体中更大。我们调查了PD患者的睡眠障碍与抑郁严重程度之间的相关性是否大于匹配的对照组（MC）。研究样本（N = 98）包括50例特发性PD患者和48例年龄、种族、性别和教育程度匹配的对照。使用匹兹堡睡眠质量指数的自我报告总睡眠时间（TST）、贝克抑郁量表第2版（BDI-II）的睡眠项目和失眠严重程度指数总分评估睡眠障碍。使用BDI‐II总分评估抑郁严重程度，不包括睡眠项目。采用斯皮尔曼相关性、卡方检验和多元回归分析评估PD和MC患者睡眠障碍与抑郁严重程度之间的相关性。Fisher's Z转换被用来检验睡眠障碍和抑郁严重程度之间的关联是否在PD患者中更强。在总样本中，TST较短、睡眠少于平时和失眠严重程度与抑郁严重程度相关，分别为rs（94）=-0.35，p = .001; rs（71）= 0.51，p < .001; rs（78）=-0.47，p < .001; rs（98）= 0.46，p < .001。PD患者的TST较短与抑郁严重程度之间的相关性大于MC患者，p <0.05。短TST可能是帕金森病患者抑郁严重程度的重要标志、预测因子或后果。
Parkinson's disease (PD) is a multisystem movement disorder associated with sleep disturbance and depression. Sleep disturbances and depression severity share a bidirectional association. This association may be greater in individuals who are more vulnerable to the deleterious consequences of sleep disturbance and depression severity. We investigated whether the association between sleep disturbances and depression severity is greater in patients with PD than in matched controls (MC). The study sample (N = 98) included 50 patients with idiopathic PD and 48 age‐, race‐, sex‐, and education‐matched controls. Sleep disturbances were assessed using self‐reported total sleep time (TST) on the Pittsburgh Sleep Quality Index, the sleep item on the Beck Depression Inventory, 2nd ed. (BDI‐II), and the Insomnia Severity Index total score. Depression severity was assessed using the BDI‐II total score, excluding the sleep item. Spearman's correlations, chi‐squared tests, and multiple regression were used to assess associations between sleep disturbances and depression severity in PD and MC. Fisher's Z transformation was used to test whether the association between sleep disturbances and depression severity was stronger in patients with PD. Shorter TST, sleeping less than usual, and insomnia severity were associated with depression severity in the total sample, r s(94) = −0.35, p = .001; r s(71) = 0.51, p < .001; r s(78) = −0.47, p < .001; r s(98) = 0.46, p < .001, respectively. The association between shorter TST and depression severity was greater in patients with PD than it was in MC, p < .05. Short TST may be an important marker, predictor, or consequence of depression severity in patients with Parkinson's disease.
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影响因子：
4.3
作者：
Chung, Seockhoon;Bohnen, Nicolaas I.;Chervin, Ronald D.
通讯作者：
Chervin, Ronald D.
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.
DOI：
10.1093/geronb/gbn037
发表时间：
2009-03-01
影响因子：
6.2
作者：
Nebes, Robert D.;Buysse, Daniel J.;Monk, Timothy H.
通讯作者：
Monk, Timothy H.
影响因子：
1.7
作者：
Drummond, SPA;Brown, GG;Gillin, JC
通讯作者：
Gillin, JC