Inflammation and cancer: how friendly is the relationship for cancer patients?
Inflammation and cancer: how friendly is the relationship for cancer patients?
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DOI：
10.1016/j.coph.2009.06.020
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发表时间：
2009-08
影响因子：
4
通讯作者：
Gehlot, Prashasnika
中科院分区：
文献类型：
--
作者：
Aggarwal, Bharat B.;Gehlot, Prashasnika
在过去的二十年中，有证据表明，在分子水平上，包括癌症在内的大多数慢性疾病都是由炎症反应失调引起的。转录因子如NF-κ B、AP-1和STAT 3及其基因产物如肿瘤坏死因子、白细胞介素-1、白细胞介素-6、趋化因子、环氧合酶-2、5脂氧合酶、基质金属蛋白酶和血管内皮生长因子、粘附分子等的鉴定为炎症在癌症中的作用提供了分子基础。这些炎症通路被烟草、压力、饮食因子、肥胖、酒精、感染因子、辐射和环境刺激所激活，这些因素加起来占所有癌症的95%。这些途径与癌症的转化、存活、增殖、侵袭、血管生成、转移、化学抗性和放射抗性有关，以至于大多数类型的癌症干细胞本身的存活和增殖似乎依赖于这些炎症途径的激活。然而，大多数证据来自临床前研究。这些通路是否在癌症患者的预防、进展、诊断、预后、复发或治疗中发挥任何作用，是本文讨论的主题。我们提供的证据表明，炎症生物标志物的抑制剂可能在预防和治疗癌症中发挥作用。
Evidence has emerged in the last two decades that at the molecular level most chronic diseases, including cancer, are caused by a dysregulated inflammatory response. The identification of transcription factors such as NF-kB, AP-1 and STAT3 and their gene products such as tumor necrosis factor, interleukin-1, interleukin-6, chemokines, cyclooxygenase-2, 5 lipooxygenase, matrix metalloproteases, and vascular endothelial growth factor, adhesion molecules and others have provided the molecular basis for the role of inflammation in cancer. These inflammatory pathways are activated by tobacco, stress, dietary agents, obesity, alcohol, infectious agents, irradiation, and environmental stimuli, which together account for as much as 95% of all cancers. These pathways have been implicated in transformation, survival, proliferation, invasion, angiogenesis, metastasis, chemoresistance, and radioresistance of cancer, so much so that survival and proliferation of most types of cancer stem cells themselves appear to be dependent on the activation of these inflammatory pathways. Most of this evidence, however, is from preclinical studies. Whether these pathways have any role in prevention, progression, diagnosis, prognosis, recurrence or treatment of cancer in patients, is the topic of discussion of this review. We present evidence that inhibitors of inflammatory biomarkers may have a role in both prevention and treatment of cancer.
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影响因子：
6.2
作者：
Ali-Fehmi, R;Che, MX;Munkarah, AR
通讯作者：
Munkarah, AR
影响因子：
3.8
作者：
Alici, Suleyman;Ugras, Serdar;Izmirli, Mustafa
通讯作者：
Izmirli, Mustafa
影响因子：
4.1
作者：
Cadden, Ian;Johnston, Brian T.;McGinty, Ann
通讯作者：
McGinty, Ann
影响因子：
11.5
作者：
Chang, BW;Kim, DH;Haffty, BG
通讯作者：
Haffty, BG
影响因子：
3.1
作者：
Arai, J;Yasukawa, M;Fujita, S
通讯作者：
Fujita, S