Getting ahead of antibiotic-resistant Staphylococcus aureus in U.S. hogs.
Getting ahead of antibiotic-resistant Staphylococcus aureus in U.S. hogs.
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DOI：
10.1016/j.envres.2021.110954
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发表时间：
2021-05
影响因子：
8.3
通讯作者：
Stewart J
中科院分区：
文献类型：
--
作者：
Rhodes S;Christenson E;Nguyen A;Larsen J;Price LB;Stewart J
金黄色葡萄球菌是一种条件致病菌，其抗生素耐药菌株已出现在工业化畜牧业和农业环境中。在美国，获得工业化畜牧业和农场一级抗生素使用数据的机会有限。因此，研究往往依赖于零售肉类作为直接动物采样的替代品。为了超越这一限制，并评估S。金黄色葡萄球菌在猪体内的定殖，我们购买了最近屠宰的猪的头部，并比较了金黄色葡萄球菌在猪体内的定殖。金黄色葡萄球菌种群在工业化养猪场饲养的那些与没有抗生素饲养的那些中的差异。S.分析金黄色葡萄球菌分离株的抗生素抗性和家畜适应性的推定基因型标记。虽然耐甲氧西林S.本研究中未检测到金黄色葡萄球菌（MRSA），所有来自工业化养猪场的猪（n=9/9）都携带多重耐药的S.金黄色葡萄球菌（MDRSA）与两个家畜适应性标记（scn阴性和克隆复合体（CC）9或398）相比，11%的猪没有抗生素（n=1/9）。来自工业化生产的猪携带家畜适应性沙门氏菌的可能性为9.0倍（95%置信区间（CI）：1.4-57.1）。金黄色葡萄球菌感染率是未使用抗生素饲养的猪的4.5倍（95%CI：1.3-15.3）。金黄色葡萄球菌（即scn阳性，CC 1），而IHO猪为11%（n=1/9）。这些结果表明，在IHO猪中使用抗生素可能使它们更有利于宿主的抗寄生虫，牲畜适应的S。金黄色葡萄球菌菌株相比，没有抗生素饲养的猪。我们的结果很重要，因为它们提供了强有力的证据表明抗生素使用实践影响了S。美国猪携带的金黄色葡萄球菌种群，支持使用一个健康框架增加对猪操作的常规监测以进行抗生素耐药性管理的需要。
Antibiotic-resistant strains of Staphylococcus aureus, an opportunistic bacterial pathogen, have emerged in industrial livestock operations and agricultural settings. In the United States, there is limited access to industrial livestock operations and farm-level antibiotic use data. As a result, studies often rely on retail meat as a proxy for direct animal sampling. To move beyond this limitation and assess S. aureus colonization in hogs, we purchased the heads of recently-slaughtered hogs and compared S. aureus populations in those raised on industrial hog operations versus those raised without antibiotics. S. aureus isolates were analyzed for antibiotic resistance and putative genotypic markers of livestock adaptation. Although methicillin-resistant S. aureus (MRSA) was not detected in this study, all of the hogs from industrial hog operations (n=9/9) carried multidrug-resistant S. aureus (MDRSA) with two livestock-adaptation markers (scn-negative and clonal complex (CC) 9 or 398) compared to 11% of hogs raised without antibiotics (n=1/9). Hogs from industrial operations were 9.0 times (95% confidence interval (CI): 1.4–57.1) as likely to carry livestock-adapted S. aureus and 4.5 times (95% CI: 1.3–15.3) as likely to carry MDRSA as hogs raised without antib io tics.Inco ntr ast,them aj orityofantibiot ic-freehogs (67%, n=6/9) contained human-adapted S. aureus (i.e. scn-positive, CC1) compared to 11% (n=1/9) of IHO hogs. These results indicate that antibiotic use in IHO hogs may make them more conducive hosts to antibiotic-resistant, livestock-adapted S. aureus strains when compared to hogs raised without antibiotics. Our results are important, as they provide strong evidence that antibiotic use practices influence the S. aureus populations carried by U.S. hogs, supporting the need for increased access to routine monitoring of hog operations for antibiotic resistance management using a One Health framework.
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影响因子：
3.7
作者：
Nadimpalli M;Stewart JR;Pierce E;Pisanic N;Love DC;Hall D;Larsen J;Carroll KC;Tekle T;Perl TM;Heaney CD
通讯作者：
Heaney CD
影响因子：
5.2
作者：
Bocher, S.;Middendorf, B.;Friedrich, A. W.
通讯作者：
Friedrich, A. W.
DOI：
10.3390/ijerph16183418
发表时间：
2019-09-02
影响因子：
--
作者：
Feingold, Beth J.;Augustino, Kerri L.;Ramsey, Keith M.
通讯作者：
Ramsey, Keith M.
影响因子：
19
作者：
Larsen, J.;Sunde, M.;Angen, O.
通讯作者：
Angen, O.
影响因子：
10.4
作者：
Nadimpalli, Maya L.;Stewart, Jill K.;Heaney, Christopher D.
通讯作者：
Heaney, Christopher D.