Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids.
Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids.
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DOI：
10.4081/ejh.2014.2249
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发表时间：
2014-05-08
期刊：
影响因子：
--
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Sun Y;Zhu L;Huang X;Zhou C;Zhang X
肌瘤周围的假包膜由压缩的肌层组成，其中包含神经和血管，这些神经和血管继续进入邻近的肌层。催产素（OXT）被认为影响子宫肌瘤切除术后的伤口愈合。与相邻肌层相比，我们确定假包膜中存在OXT和蛋白基因产物9.5 （PGP9.5）免疫反应性神经纤维。本文从57例子宫肌瘤切除术患者中采集假包膜及邻近肌层（N=106），用抗oxt和PGP 9.5抗体进行染色，证实神经纤维的存在。假包膜神经纤维OXT染色阳性（89/106,84.0%），PGP染色阳性（94/106,88.7%）。假包膜中PGP 9.5和OXT染色的神经纤维密度在峡部最高（分别为23.68±22.45/mm2和43.35±40.74/mm2）。无论子宫肌瘤的位置如何，假包膜与相邻正常子宫肌层的神经纤维密度在OXT或PGP 9.5染色下均无显著差异（P < 0.05）。这些结果表明假包膜应避免在子宫肌瘤切除术过程中被破坏。
The pseudocapsule surrounding fibroids consists of compressed myometrium containing nerves and blood vessels that continue into adjacent myometrium. Oxytocin (OXT) is thought to affect wound healing after myomectomy. We determined the presence of OXT and protein gene product 9.5 (PGP9.5) immunoreactive nerve fibers in pseudocapsule compared to adjacent myometrium. Samples (N=106) of pseudocapsule and adjacent myometrium were collected from 57 women with uterine fibroids undergoing myomectomy, and stained with anti-OXT and PGP 9.5 antibodies to demonstrate the presence of nerve fibers. Nerve fibers in the pseudocapsule stained positively with OXT (89/106, 84.0%) and PGP 9.5 (94/106, 88.7%). The densities of nerve fibers staining with PGP 9.5 and OXT in the pseudocapsule were highest in the isthmus (23.68±22.45/mm2 and 43.35±40.74/mm2, respectively). There were no significant differences in the density of nerve fibers, stained with either OXT or PGP 9.5, between the pseudocapsule, and adjacent normal myometrium regardless of the fibroid location in the uterus (P>0.05). These results suggest that the pseudocapsule should avoid to be damaged during the myomectomy procedure.
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