Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients.
Arterial-Arteriolar Sclerosis Is Independently Associated With Poor Renal Outcome in IgA Nephropathy Patients.
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DOI：
10.3389/fmed.2021.761897
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发表时间：
2021
影响因子：
3.9
通讯作者：
Qin W
中科院分区：
文献类型：
--
作者：
Dong L;Tan J;Li F;Wang S;Jiang Z;Qin A;Zhong Z;Zhou X;Tang Y;Qin W
目标：本研究旨在探讨免疫球蛋白A肾病（IgAN）合并小动脉硬化（AS）的临床病理特征及预后。方法：回顾性分析四川大学华西医院经病理证实的IgA肾病患者。收集临床病理特征。根据AS的存在和严重程度对患者进行分类。所有患者均定期随访，直至复合终点。分析AS与IgAN预后的关系。结果：共招募了1，424例患者，随访时间为60.0 ± 28.7个月。AS患者年龄大、血压高、蛋白尿多、血清肌酐、尿酸和总甘油三酯（TG）高。同时，他们更可能有较低的估计肾小球滤过率（eGFR），血红蛋白和白蛋白。随访结束时，AS组有126例患者和非AS组有47例患者达到复合终点（p < 0.001）。AS与肾脏预后相关（对数秩检验p < 0.001），是IgAN进展的独立危险因素（p = 0.049）。AS的严重程度与肾脏预后相关（对数秩p < 0.001），并且有可能作为IgAN进展的独立风险标志物的趋势。在亚组分析中，出现AS和较低eGFR、白蛋白和血红蛋白或较高蛋白尿、尿酸和TG的患者具有达到终点的时间较短的显著趋势（对数秩p < 0.001）。结论：AS在IgAN患者中较常见，与预后不良独立相关。
Aim: This study aimed to investigate the clinicopathological features and prognosis of immunoglobulin A nephropathy (IgAN) with arterial-arteriolar sclerosis (AS). Methods: Patients with biopsy-proven IgAN from the West China Hospital of Sichuan University were retrospectively enrolled. Clinicopathological features were collected. Patients were categorized based on the presence and the severity of the AS. All the patients were regularly followed-up until a composite end point. The correlation between AS and prognosis of IgAN was assessed. Results: A total of 1,424 patients were recruited and followed for 60.0 ± 28.7 months. Patients with AS tended to have older age, higher blood pressure, heavier proteinuria, higher serum creatinine, uric acid, and total triglyceride (TG). Meanwhile, they were more likely to have a lower estimated glomerular filtration rate (eGFR), hemoglobin, and albumin. At the end of follow-up, 126 patients in the AS group and 47 patients in the non-AS group had reached the composite end point (p < 0.001). AS was associated with the renal outcome (log-rank p < 0.001) and was an independent risk factor for the progression of IgAN (p = 0.049). The severity of AS was associated with renal outcomes (log-rank p < 0.001) and there was a trend that it might serve as an independent risk marker for progression of IgAN. In the subgroup analysis, patients presenting with AS and lower eGFR, albumin, and hemoglobin or higher proteinuria, uric acid, and TG had a significant trend for a shorter time to reach the end point (log-rank p < 0.001). Conclusion: AS was commonly seen in patients with IgAN and was independently associated with the poor prognosis.
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影响因子：
4.6
作者：
Afsar B;Afsar RE;Dagel T;Kaya E;Erus S;Ortiz A;Covic A;Kanbay M
通讯作者：
Kanbay M
DOI：
10.1016/j.numecd.2020.07.038
发表时间：
2020-11-27
影响因子：
3.9
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影响因子：
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作者：
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