A dynamic flux in natural killer cell subsets as a function of the duration of alcohol ingestion.
A dynamic flux in natural killer cell subsets as a function of the duration of alcohol ingestion.
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DOI：
10.1111/j.1530-0277.2011.01678.x
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Coleman RA
中科院分区：
文献类型：
--
作者：
Ballas ZK;Cook RT;Shey MR;Coleman RA
慢性乙醇消耗与多种免疫异常相关，包括T细胞、B细胞、树突细胞和自然杀伤（NK）细胞的变化。然而，关于这种免疫变化的方向存在相互矛盾的信息。在本报告中测试的假设是，对于NK细胞，变化可以作为酒精摄入持续时间的函数而变化。使用慢性酒精摄入的Meadows-Cook鼠模型，检查NK细胞功能和亚群分布的变化作为酒精摄入持续时间的函数。急性酒精摄入导致NK细胞的数量和细胞毒性功能降低，而对细胞内干扰素γ表达没有影响。这些异常在摄入酒精12 - 14天后正常化，并且在持续摄入ETOH 8周后NK细胞数量和细胞毒性增加。持续饮酒10周导致Ly49H + CD11b + CD27 −脾NK细胞亚群显著减少;这种差异在30周时仍然显著。这份报告可能解释了一些相互矛盾的数据在文献中，检查了酒精患者的NK细胞活性。很明显，在NK细胞活性和亚群分布中可以看到各种异常，其中通量是酒精摄入持续时间的函数。Ly49H+亚群（已知参与抵抗小鼠CMV感染）减少的证明可能解释了慢性酒精滥用中报告的某些病毒感染易感性增加。另一个新的发现是，NK细胞的某些亚群的变化在持续摄入ETOH至少10周之前并不明显。
Chronic ethanol consumption is associated with a wide variety of immune abnormalities including changes in T cells, B cells, dendritic cells and Natural Killer (NK) cells. However, there is conflicting information as to the direction of such immune changes. The hypothesis that was tested in this report is that, for NK cells, the changes can vary as a function of the duration of alcohol ingestion. Using the Meadows-Cook murine model of chronic alcohol ingestion, the changes in NK cell function and subset distribution were examined as a function of the duration of alcohol ingestion Acute Alcohol ingestion resulted in decreased number and cytotoxic function of NK cells with no effect on intracellular interferon gamma expression. These abnormalities normalized after 12–14 days of alcohol ingestion and there was an increase of NK cell number and cytotoxicity after eight weeks of continued ETOH ingestion.. Ten weeks of continued alcohol consumption results in a significant decrease in the Ly49H+ CD11b+ CD27− splenic NK cell subset; this difference continued to be significant at 30 weeks. This report may explain some of the conflicting data in the literature that examined NK cell activity in alcoholic patients. It is apparent that various abnormalities can be seen in NK cell activity and subset distribution with the flux being a function of the duration of alcohol ingestion. The demonstration of a decrease in the Ly49H+ subset (which is known to be involved in resisting murine CMV infection) may explain the reported increase in susceptibility to some viral infections in chronic alcohol abuse. Another novel finding is that changes of some subsets of NK cells are not evident until at least ten weeks of continued ETOH consumption.
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影响因子：
4.4
作者：
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通讯作者：
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DOI：
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作者：
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DOI：
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发表时间：
2003-04-01
影响因子：
3.2
作者：
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通讯作者：
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