The co-ordinated cytokine/hormone response to acute injury incorporates leptin.
The co-ordinated cytokine/hormone response to acute injury incorporates leptin.
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对急性损伤的协调细胞因子/激素反应包括瘦素。
DOI：
10.1006/cyto.2000.0674
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发表时间：
2000
期刊：
影响因子：
3.8
通讯作者：
Donald C. McMillan
中科院分区：
文献类型：
--
作者：
A. Wallace;Naveed Sattar;Donald C. McMillan
最近的研究表明瘦素是一种“应激”激素，并强调了它与炎症细胞因子、C反应蛋白和皮质醇增加的关系。为了研究瘦素对应激的确切时间反应，我们对明确的胆囊切除术损伤期间循环瘦素浓度进行了详细的纵向研究。在9例患者手术开始后3、6、9、12、18、24、48和72 h测量皮质醇、游离脂肪酸、瘦素和C-反应蛋白的循环浓度。基线瘦素浓度与BMI之间存在显著相关性（r=0. 999，P < 0. 05）。893，P<0.001）。在手术开始后72小时内，所有分析物的浓度（峰值中位浓度）均显著增加（P<0.05）;皮质醇（6小时）、游离脂肪酸（9小时）、瘦素（18小时）和C-反应蛋白（48小时）。有趣的是，瘦素在急性炎症刺激后约18小时达到峰值的时间与先前报道的白细胞介素6完全相同。这些数据支持皮质醇和瘦素之间的关系反映了皮质醇和另一种细胞因子白细胞介素6的关系，即在急性情况下具有刺激性，在慢性情况下具有抑制性。它们还暗示瘦素在急性损伤中的生理作用。
Recent studies have implicated leptin as a "stress" hormone and highlighted its association with increases in inflammatory cytokines, C-reactive protein and cortisol. In order to investigate the exact temporal leptin response to stress we undertook a detailed longitudinal study of circulating leptin concentrations during the well defined surgical injury of cholecystectomy. Circulating concentrations of cortisol, free fatty acids, leptin and C-reactive protein were measured at 3, 6, 9, 12, 18, 24, 48 and 72 h from the start of surgery in nine patients. There was a significant correlation between baseline concentrations of leptin and BMI (r=0. 893, P<0.001). Over the 72 h from the start of surgery there were significant (P<0.05) increases in the concentrations of all analytes (peak median concentrations); cortisol (6 h), free fatty acids (9 h), leptin (18 h) and C-reactive protein (48 h). Interestingly the timing of the leptin peak at approximately 18 h after an acute inflammatory stimulus is exactly the same as previously reported for interleukin 6. These data support the suggestion that the relationship between cortisol and leptin mirrors that of cortisol and another cytokine, interleukin 6, i.e. stimulatory in acute and suppressive in chronic situations. They also imply a physiological role for leptin in acute injury.
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DOI：
10.1073/pnas.84.23.8619
发表时间：
1987
影响因子：
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作者：
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通讯作者：
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影响因子：
3.8
作者：
Rock,CS;Coyle,SM;Keogh,CV;Lazarus,DD;Hawes,AS;Leskiw,M;Moldawer,LL;Stein,TP;Lowry,SF
通讯作者：
Lowry,SF