Effects of soy containing diet and isoflavones on cytochrome P450 enzyme expression and activity.
Effects of soy containing diet and isoflavones on cytochrome P450 enzyme expression and activity.
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DOI：
10.1080/03602532.2016.1206562
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发表时间：
2016-08
影响因子：
5.9
通讯作者：
Ronis MJ
中科院分区：
文献类型：
--
作者：
Ronis MJ
细胞色素P450(CYP)在大多数临床用药和其他外来物质的代谢和清除中起着重要的作用。它们在包括脂肪酸、类固醇、类固醇和脂溶维生素在内的内源化合物的代谢中起着重要作用。饮食因素，如植物化学物质，能够影响CYP的表达和活性，这在饮食与药物的相互作用以及脂肪肝、心血管疾病和癌症的发展中可能是重要的。一种重要的饮食-CYP相互作用是与含有植物蛋白的饮食相互作用，特别是大豆蛋白。大豆饮食是亚洲国家的传统饮食，与亚洲人群中几种癌症和心血管疾病的较低发病率有关。大豆也是素食和纯素食饮食中的重要蛋白质来源，也是大豆婴儿配方奶粉中唯一的蛋白质来源。最近的研究表明，食用大豆可以抑制多环芳烃对Cy1酶的诱导，这可能有助于预防癌症。此外，有数据表明，大豆成分混杂地激活了几个核受体，包括PXR、PPAR和LXR，导致参与胆固醇代谢为胆汁酸的CyP3As、CyP4As和Cyps的表达增加。大豆-CYP的这种相互作用可能会改变药物的药代动力学和治疗效果，并与改善脂质稳态和降低心血管疾病的风险有关。本文综述了大豆-CYP相互作用的体外、体内和临床研究结果，并考察了大豆日粮对CYP表达的影响与异黄酮类植物雌激素，特别是与大豆蛋白相关的染料木素和大豆苷元之间联系的证据。
Cytochrome P450s (CYP) plays an important role in metabolism and clearance of most clinically utilized drugs and other xenobiotics. They are important in metabolism of endogenous compounds including fatty acids, sterols, steroids and lipid soluble vitamins. Dietary factors such as phytochemicals are capable of affecting CYP expression and activity which may be important in diet-drug interactions and in development of fatty liver disease, cardiovascular disease and cancer. One important diet-CYP interaction is with diets containing plant proteins, particularly soy protein. Soy diets are traditionally consumed in Asian countries and are linked to lower incidence of several cancers and of cardiovascular disease in Asian populations. Soy is also an important protein source in vegetarian and vegan diets and the sole protein source in soy infant formulas. Recent studies suggest that consumption of soy can inhibit induction of CY1 enzymes by polycyclic aromatic hydrocarbons which may contribute to cancer prevention. In addition, there is data to suggest that soy components promiscuously activate several nuclear receptors including PXR, PPAR and LXR resulting in increased expression of CYP3As, CYP4As and CYPs involved in metabolism of cholesterol to bile acids. Such soy-CYP interactions may alter drug pharmacokinetics and therapeutic efficacy and be associated with improved lipid homeostasis and reduced risk of cardiovascular disease. The current review summarizes results from in vitro; in vivo and clinical studies of soy-CYP interactions and examines the evidence linking the effects of soy diets on CYP expression to isoflavone phytoestrogens, particularly genistein and daidzein which are associated with soy protein.
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影响因子：
5.9
作者：
Dinsdale EC;Ward WE
通讯作者：
Ward WE
DOI：
10.1016/j.jsbmb.2005.02.002
发表时间：
2005-04-01
影响因子：
4.1
作者：
Brooks, JD;Thompson, LU
通讯作者：
Thompson, LU
DOI：
10.1165/ajrcmb.22.3.3845
发表时间：
2000-03-01
影响因子：
6.4
作者：
Hukkanen, J;Lassila, A;Raunio, H
通讯作者：
Raunio, H
影响因子：
2.9
作者：
Hardwick JP;Osei-Hyiaman D;Wiland H;Abdelmegeed MA;Song BJ
通讯作者：
Song BJ
影响因子：
6.7
作者：
Hamilton-Reeves, Jill M.;Vazquez, Gabriela;Messina, Mark J.
通讯作者：
Messina, Mark J.