Personalized protein corona on nanoparticles and its clinical implications.
Personalized protein corona on nanoparticles and its clinical implications.
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DOI：
10.1039/c6bm00921b
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发表时间：
2017-02-28
影响因子：
6.6
通讯作者：
Mahmoudi M
中科院分区：
文献类型：
--
作者：
Corbo C;Molinaro R;Tabatabaei M;Farokhzad OC;Mahmoudi M
现在已经很好地理解，一旦与生物液体接触，纳米级物体就会失去其原始身份并获得新的生物特征，称为蛋白质冠。蛋白质冠改变纳米颗粒的许多物理化学性质，包括尺寸、表面电荷和聚集状态。这些变化反过来影响纳米颗粒的生物学命运，包括其药代动力学、生物分布和治疗功效。逐渐被接受的是，即使蛋白质源的组成的微小变化（例如，血浆和血清）可以基本上改变在完全相同的纳米颗粒表面上形成的冠的组成。最近，它已被证明，蛋白质冠是强烈影响病人的具体疾病。因此，与具有不同病理的患者的血浆蛋白孵育的相同纳米材料吸附具有不同组成的蛋白质冠，从而产生个性化蛋白质冠的概念。在此，我们回顾这一概念沿着的最新进展的主题，特别关注临床相关性。
It is now well understood that once in contact with biological fluids, nanoscale objects lose their original identity and acquire a new biological character, referred to as a protein corona. The protein corona changes many of the physicochemical properties of nanoparticles, including size, surface charge, and aggregation state. These changes, in turn, affect the biological fate of nanoparticles, including their pharmacokinetics, biodistribution, and therapeutic efficacy. It is progressively being accepted that even slight variations in the composition of a protein source (e.g., plasma and serum) can substantially change the composition of the corona formed on the surface of the exact same nanoparticles. Recently it has been shown that the protein corona is strongly affected by the patient’s specific disease. Therefore, the same nanomaterial incubated with plasma proteins of patients with different pathologies adsorb protein coronas with different compositions, giving rise to the concept of personalized protein corona. Herein, we review this concept along with recent advances on the topic, with a particular focus on clinical relevance.
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影响因子：
2.9
作者：
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通讯作者：
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作者：
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