Reversible nerve conduction block using kilohertz frequency alternating current.
Reversible nerve conduction block using kilohertz frequency alternating current.
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DOI：
10.1111/ner.12100
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Bhadra N
中科院分区：
文献类型：
--
作者：
Kilgore KL;Bhadra N
综述了平衡电荷千赫频率交流电的特点和临床应用。KHFAC的临床前研究表明，它可以产生极其快速和可逆的神经传导阻滞。最近利用KHFAC块进行的系统分析和实验导致了科学和临床上对KHFAC块的兴趣的显著增加。我们回顾了KHFAC闭塞的历史和特点，研究这种闭塞的方法，闭塞的实验评价，以及实现成功闭塞所需的电气参数和电极设计。然后，我们分析了高频电流的现有临床应用，将早期结果与KHFAC块的已知特征进行了比较。尽管KHFAC块的许多特征已经被描述，但关于神经结构对快速波动电场的响应仍有许多未知之处。到目前为止，临床报告没有提供足够的信息来正确评估导致治疗成功或失败的机制。KHFAC神经阻滞作为一种控制神经活动以治疗疾病的手段具有巨大的潜力。然而，使用高频电流治疗疼痛的早期临床研究并未被设计为阐明机制或允许与临床前数据进行直接比较。我们强烈鼓励仔细报告这些临床研究中使用的参数，以及开发能够阐明这种模式的机制的结果测量方法。
The features and clinical applications of balanced-charge kilohertz frequency alternating currents (KHFAC) are reviewed. Preclinical studies of KHFAC block have demonstrated that it can produce an extremely rapid and reversible block of nerve conduction. Recent systematic analysis and experimentation utilizing KHFAC block has resulted in a significant increase in interest in KHFAC block, both scientifically and clinically. We review the history and characteristics of KHFAC block, the methods used to investigate this type of block, the experimental evaluation of block, and the electrical parameters and electrode designs needed to achieve successful block. We then analyze the existing clinical applications of high frequency currents, comparing the early results with the known features of KHFAC block. Although many features of KHFAC block have been characterized, there is still much that is unknown regarding the response of neural structures to rapidly fluctuating electrical fields. The clinical reports to date do not provide sufficient information to properly evaluate the mechanisms that result in successful or unsuccessful treatment. KHFAC nerve block has significant potential as a means of controlling nerve activity for the purpose of treating disease. However, early clinical studies in the use of high frequency currents for the treatment of pain have not been designed to elucidate mechanisms or allow direct comparisons to preclinical data. We strongly encourage the careful reporting of the parameters utilized in these clinical studies, as well as the development of outcome measures that could illuminate the mechanisms of this modality.
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DOI：
10.1002/jbm.b.31223
发表时间：
2009-05
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Cogan SF;Ehrlich J;Plante TD;Smirnov A;Shire DB;Gingerich M;Rizzo JF
通讯作者：
Rizzo JF
影响因子：
4
作者：
Ackermann DM;Bhadra N;Gerges M;Thomas PJ
通讯作者：
Thomas PJ
影响因子：
5.5
作者：
Cattell, M;Gerard, RW
通讯作者：
Gerard, RW
影响因子：
6.6
作者：
Abdel-Gawad, M;Boyer, S;Elhilali, MM
通讯作者：
Elhilali, MM
影响因子：
3.4
作者：
Bhadra, N;Kilgore, KL
通讯作者：
Kilgore, KL