Effect of lactobacilli on paracellular permeability in the gut.
Effect of lactobacilli on paracellular permeability in the gut.
复制标题
DOI：
10.3390/nu3010104
复制
发表时间：
2011-01
期刊：
影响因子：
5.9
通讯作者：
Hagslatt ML
中科院分区：
文献类型：
--
作者：
Ahrne S;Hagslatt ML
细胞旁通透性由位于上皮细胞之间的连接的复杂结构决定。早在 1996 年，研究就表明，人类益生菌菌株植物乳杆菌 299v 和源自大鼠的菌株罗伊氏乳杆菌 R2LC 可以在甲氨蝶呤诱导的大鼠结肠炎模型中降低这种渗透性。随后，许多动物模型和细胞培养系统表明，乳酸菌能够抵抗细胞因子、化学物质、感染或应激引起的细胞旁通透性增加。很少有人类研究关注乳酸杆菌对肠道旁细胞通透性的影响，但最近发现它们可以影响紧密连接。更准确地说，对健康志愿者短期施用植物乳杆菌 WCSF1 会增加 occludin 和 ZO-1 重新定位到十二指肠上皮细胞之间的紧密连接区域。
Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the tight junctions. More precisely, short-term administration of L. plantarum WCSF1 to healthy volunteers increased the relocation of occludin and ZO-1 into the tight junction area between duodenal epithelial cells.
登录
查看更多内容
DOI：
10.1016/j.alcohol.2008.12.009
发表时间：
2009-03
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Forsyth CB;Farhadi A;Jakate SM;Tang Y;Shaikh M;Keshavarzian A
通讯作者：
Keshavarzian A
影响因子：
14.2
作者：
Groschwitz, Katherine R.;Hogan, Simon P.
通讯作者：
Hogan, Simon P.
影响因子：
13.5
作者：
Adawi, D;Kasravi, FB;Jeppsson, B
通讯作者：
Jeppsson, B
DOI：
10.1111/j.1749-6632.2009.04025.x
发表时间：
2009-01-01
期刊：
MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS
影响因子：
--
作者：
Koch, Stefan;Nusrat, Asma
通讯作者：
Nusrat, Asma
影响因子：
13.5
作者：
Ewaschuk, Julia;Endersby, Ryan;Madsen, Karen
通讯作者：
Madsen, Karen