Timing in the absence of supraspinal input III: regularly spaced cutaneous stimulation prevents and reverses the spinal learning deficit produced by peripheral inflammation.
Timing in the absence of supraspinal input III: regularly spaced cutaneous stimulation prevents and reverses the spinal learning deficit produced by peripheral inflammation.
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DOI：
10.1037/a0022009
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发表时间：
2011-02
影响因子：
1.9
通讯作者：
Grau, James W.
中科院分区：
文献类型：
--
作者：
Baumbauer, Kyle M.;Grau, James W.
在没有大脑输入的情况下，脊柱系统可以适应新的环境关系。例如，脊髓横断大鼠每次腿部伸展时给予腿部电击，表现出屈曲持续时间的逐渐增加，使净电击暴露最小化，这是一种简单的工具性学习形式。这种学习能力受到先前刺激的调节;可变的休克和炎症都对学习产生持久的抑制。长时间暴露于固定间隔的电击对学习没有不利影响，并与可变电击的后果相反。本研究扩展了这些发现，并证明固定刺激改善了外周炎症的影响。脊髓横断大鼠给予900个固定的间隔腿部电击之前（实验1）或1800个腿部电击后（实验2）皮下注射辣椒素。24小时后评估学习情况。固定电击可减弱辣椒素引起的学习抑制。这些发现表明，固定刺激促进适应性可塑性，并可能促进损伤后的恢复。
In the absence of brain input, spinal systems can adapt to new environmental relations. For example, spinally transected rats given a legshock each time the leg is extended exhibit a progressive increase in flexion duration that minimizes net shock exposure, a simple form of instrumental learning. This capacity for learning is modulated by prior stimulation; both variable shock and inflammation produce a lasting inhibition of learning. An extended exposure to fixed spaced shock has no adverse effect on learning and opposes the consequences of variable shock. The present studies expand on these findings and demonstrate that fixed stimulation ameliorates the impact of peripheral inflammation. Spinally transected rats were administered 900 fixed spaced legshocks prior to (Experiment 1) or 1800 legshocks following (Experiment 2) a subcutaneous hindpaw injection of capsaicin. Learning was assessed 24 hr later. Treatment with fixed shock attenuated the capsaicin-induced inhibition of learning. These findings suggest that fixed stimulation promotes adaptive plasticity and may foster recovery after injury.
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影响因子：
2.5
作者：
Crown, ED;Grau, JW
通讯作者：
Grau, JW
影响因子：
2.9
作者：
Crown, ED;Ferguson, AR;Grau, JW
通讯作者：
Grau, JW
影响因子：
1.9
作者：
Grau, JW;Barstow, DG;Joynes, RL
通讯作者：
Joynes, RL
影响因子：
1.9
作者：
Crown, ED;Ferguson, AR;Grau, JW
通讯作者：
Grau, JW
影响因子：
5.4
作者：
GROVES P M;THOMPSON R F
通讯作者：
THOMPSON R F