Pseudomembranous conjunctivitis with hand, foot and mouth disease in a pregnant woman : a case report.
Pseudomembranous conjunctivitis with hand, foot and mouth disease in a pregnant woman : a case report.
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DOI：
10.1186/s12886-021-01878-7
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发表时间：
2021-03-02
影响因子：
2
通讯作者：
Kim TG
中科院分区：
文献类型：
--
作者：
Kim YJ;Kim TG
手足口病 (HFMD) 是一种常见的全身感染，由肠道病毒（通常是柯萨奇 A16）引起。一般来说，它影响儿童或免疫功能低下的成年人。只有少数报告描述了与手足口病相关的伪膜性结膜炎。我们的目的是描述一名 37 岁女性，患有手足口病，并发严重伪膜性结膜炎，怀孕 28 周，其临床结果和眼部表现。一名怀孕 28 周的女性患者因双眼疼痛和注射而转诊至眼科复查。该患者住院接受妇产科检查，并接受了白塞氏病（伴有口腔和会阴溃疡）的评估。在眼科检查中，发现双眼有结膜充血。诊断为白塞病相关结膜炎。每 6 小时施用一次局部类固醇和抗生素。就诊两天后，她的手掌出现了斑丘疹。血清病毒抗体检测检出肠道病毒71型，诊断为手足口病。 7天后，双眼出现严重的伪膜性结膜炎和角膜上皮缺损。每 3 小时给予一次局部类固醇，每 2 至 3 天去除假膜。 3周后假膜未出现，但角膜糜烂持续存在。 3个月后，角膜糜烂完全消失。手足口病相关结膜炎是成人罕见的并发症，但也可能表现为严重的假膜性结膜炎。在这种情况下，去除假膜和局部类固醇有助于改善症状。
Hand, foot, and mouth disease (HFMD) is a common systemic infection that is caused by an enterovirus, normally Coxsackie A16. Generally, it affects children or immunocompromised adults. Only a few reports have described pseudomembranous conjunctivitis associated with HFMD. We aim to describe the clinical outcomes and ocular findings of a 37-year-old female with HFMD and concurrent severe pseudomembranous conjunctivitis, who was 28 weeks pregnant. A female patient who was 28-weeks pregnant was referred for an ophthalmological review due to pain and injection in both eyes. The patient was hospitalized under obstetrics and gynecology and evaluated for Behcet’s disease with oral and perineal ulcers. In an ophthalmic examination, both eyes were observed to have a conjunctival injection. Behcet’s disease-associated conjunctivitis was diagnosed. Topical steroids and antibiotics were administered every 6 h. Two days after her presentation, a maculopapular eruption occurred on her palms. Enterovirus type 71 was detected in a serum virus antibody test, and the patient was diagnosed with HFMD. After 7 days, severe pseudomembranous conjunctivitis and corneal epithelial defects occurred in both eyes. Topical steroids were administered every 3 h, and the pseudomembrane was removed every 2 to 3 days. The pseudomembrane did not occur after 3 weeks, but corneal erosion persisted. After 3 months, the corneal erosion had completely resolved. HFMD-associated conjunctivitis is a rare complication in adults, however it can appear as a severe pseudomembranous conjunctivitis. In this case, the removal of the pseudomembrane and topical steroids helped improve the symptoms.
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影响因子：
--
作者：
YANNUZZI, LA;JAMPOL, LM;WILCOX, LM
通讯作者：
WILCOX, LM
影响因子：
1.7
作者：
Demirel, Sibel;Batioglu, Figen;Ozmert, Emin
通讯作者：
Ozmert, Emin
影响因子：
3.1
作者：
Wang, Min;Ren, Qian;Shi, Weifeng
通讯作者：
Shi, Weifeng
DOI：
10.1016/s1091-8531(97)90011-2
发表时间：
1997-06-01
期刊：
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
影响因子：
--
作者：
Brown, S M
通讯作者：
Brown, S M
影响因子：
3.1
作者：
Tsao, KC;Chang, PY;Shih, SR
通讯作者：
Shih, SR