Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics
Offline memory replay in recurrent neuronal networks emerges from constraints on online dynamics
复制标题
循环神经网络中的离线记忆重放源于在线动态的限制
DOI：
10.1113/jp283216
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Soltesz, Ivan
中科院分区：
文献类型：
--
作者：
Milstein, Aaron D.;Tran, Sarah;Ng, Grace;Soltesz, Ivan
摘要在空间探索过程中，海马体中的神经回路储存了在环境中遇到的一系列感觉事件的记忆。当感官信息在“离线”休息期间缺失时，短暂的神经元群体爆发可以“重放”类似于感官体验的活动序列。这些序列可以以正向或反向顺序发生，甚至可以包括尚未经历过的空间轨迹，但与环境的拓扑结构一致。这种可变和灵活的序列生成背后的神经回路机制是未知的。在这里，我们证明了在一个经常性的尖峰网络模型的海马CA3区的网络动态，如人口稀疏性，刺激选择性，节律性和尖峰频率适应，以及关联突触连接，实验约束，使额外的紧急属性，包括变量离线记忆重放。在一个在线刺激驱动的状态下，我们观察到神经元序列的出现，这些序列在θ节律的时间尺度上从过去的刺激到未来的刺激。在仅由噪声驱动的离线状态下，该网络生成了正向和反向神经元序列，并概括了实验观察结果，即离线记忆重放事件往往包括突出的位置，如奖励的位置。这些结果表明，对递归神经回路动力学的生物学约束足以使存储在突触连接强度中的感觉事件的记忆在休息和睡眠期间灵活地读出，关键点我们对海马CA3区的一个循环发放网络模型进行了优化，以重现实验观察到的网络模拟空间探索期间的动态。在模拟离线休息期间，网络表现出产生灵活向前的涌现特性，反向和混合方向记忆重放事件。网络扰动和模型多样性和退化的分析确定了关联突触连接和网络动力学的关键特征对于离线序列生成很重要。网络模拟表明，显著位置的群体过度表示就像奖励的地点会导致有偏见的记忆回放。
AbstractDuring spatial exploration, neural circuits in the hippocampus store memories of sequences of sensory events encountered in the environment. When sensory information is absent during ‘offline’ resting periods, brief neuronal population bursts can ‘replay’ sequences of activity that resemble bouts of sensory experience. These sequences can occur in either forward or reverse order, and can even include spatial trajectories that have not been experienced, but are consistent with the topology of the environment. The neural circuit mechanisms underlying this variable and flexible sequence generation are unknown. Here we demonstrate in a recurrent spiking network model of hippocampal area CA3 that experimental constraints on network dynamics such as population sparsity, stimulus selectivity, rhythmicity and spike rate adaptation, as well as associative synaptic connectivity, enable additional emergent properties, including variable offline memory replay. In an online stimulus‐driven state, we observed the emergence of neuronal sequences that swept from representations of past to future stimuli on the timescale of the theta rhythm. In an offline state driven only by noise, the network generated both forward and reverse neuronal sequences, and recapitulated the experimental observation that offline memory replay events tend to include salient locations like the site of a reward. These results demonstrate that biological constraints on the dynamics of recurrent neural circuits are sufficient to enable memories of sensory events stored in the strengths of synaptic connections to be flexibly read out during rest and sleep, which is thought to be important for memory consolidation and planning of future behaviour.Key pointsA recurrent spiking network model of hippocampal area CA3 was optimized to recapitulate experimentally observed network dynamics during simulated spatial exploration.During simulated offline rest, the network exhibited the emergent property of generating flexible forward, reverse and mixed direction memory replay events.Network perturbations and analysis of model diversity and degeneracy identified associative synaptic connectivity and key features of network dynamics as important for offline sequence generation.Network simulations demonstrate that population over‐representation of salient positions like the site of reward results in biased memory replay.
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DOI：
10.1523/jneurosci.20-19-07463.2000
发表时间：
2000-10
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
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通讯作者：
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影响因子：
56.9
作者：
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影响因子：
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影响因子：
25
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影响因子：
16.2
作者：
Juan F. Ramirez;K. Willeke;N. Logothetis;M. Besserve
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