Photoaging and topical tretinoin: therapy, pathogenesis, and prevention.
Photoaging and topical tretinoin: therapy, pathogenesis, and prevention.
复制标题
光老化和局部维A酸：治疗、发病机制和预防。
DOI：
10.1001/archderm.1997.03890460104012
复制
发表时间：
1997
影响因子：
--
通讯作者：
J. J. Voorhees
中科院分区：
文献类型：
--
作者：
Sewon Kang;G. Fisher;J. J. Voorhees
反复暴露在太阳的紫外线辐射下会导致皮肤过早老化。这种光老化的特征是皱纹、斑驳的色素、干燥和粗糙的皮肤，以及皮肤色泽的丧失。自从临床证明局部使用维甲酸可以改善光老化的皮肤以来，人们已经获得了许多可以解释皱纹消失的知识。这一追求的核心是真皮胶原蛋白。在这篇文章中，我们总结了(主要来自人类)的证据，表明真皮表层胶原蛋白的缺乏是光老化的真皮方面的原因。此外，还提出了紫外线辐射导致胶原减少的机制。通过我们对光老化的病理生理机制的了解，我们治疗和预防这种皮肤疾病的能力得到了增强。
Repeated exposure to UV radiation from the sun causes premature skin aging. This photoaging is characterized by wrinkles, mottled pigmentations, dry and rough skin, and loss of skin tone. Since the clinical demonstration that the use of topical tretinoin can improve photoaged skin, a great deal of knowledge that may explain wrinkle effacement has been acquired. Central to this pursuit has been dermal collagen. In this article, we summarize evidence (mainly from humans) that implicates a deficiency of superficial dermal collagen as the cause of the dermal aspects of photoaging. In addition, a mechanism through which UV radiation can lead to reduced collagen is presented. Through our understanding of the pathophysiological mechanism of photoaging, our ability to treat and possibly prevent this skin condition is enhanced.
登录
查看更多内容
DOI：
10.1111/1523-1747.ep12481920
发表时间：
1991-09
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
D. Woodley;M. Yamauchi;K. Wynn;G. Mechanic;R. A. Briggaman
通讯作者：
D. Woodley;M. Yamauchi;K. Wynn;G. Mechanic;R. A. Briggaman
影响因子：
--
作者：
SMITH, LT;HOLBROOK, KA;MADRI, JA
通讯作者：
MADRI, JA
影响因子：
--
作者：
Matrisian, L.M.;Hogan, B.L.M.
通讯作者：
Hogan, B.L.M.
影响因子：
158.5
作者：
GRIFFITHS, CEM;RUSSMAN, AN;VOORHEES, JJ
通讯作者：
VOORHEES, JJ