XRCC1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis through suppressing MMP-2 and MMP-9.
XRCC1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis through suppressing MMP-2 and MMP-9.
复制标题
XRCC1作为透明细胞肾细胞癌的潜在预后指标，通过抑制MMP-2和MMP-9来抑制其侵袭和转移
DOI：
10.18632/oncotarget.22680
复制
发表时间：
2017-12-12
期刊：
影响因子：
--
通讯作者：
Zheng JN
中科院分区：
文献类型：
--
作者：
Liu QH;Wang Y;Yong HM;Hou PF;Pan J;Bai J;Zheng JN
X射线修复交叉互补基因1(XRCC1)是一种主要的DNA修复基因，通过与损伤部位的DNA组分相互作用，修复DNA碱基损伤和单链断裂。本研究探讨XRCC1在人肾透明细胞癌中的临床意义，并进一步探讨XRCC1在肾透明细胞癌中的作用机制。使用组织芯片和两个独立的人肾细胞癌队列的免疫组织化学染色来评估XRCC1在肾细胞癌中的临床相关性。我们的数据显示，XRCC1在肾细胞癌组织中的表达显著低于正常肾组织和配对的癌旁非肿瘤组织。通过LOG-RANK检验，XRCC1低表达与患者的淋巴转移显著相关，并与患者总体和疾病特异性生存较差相关。然而，COX回归分析显示，XRCC1的表达不是ccRCC患者的独立预后因素。此外，XRCC1通过调节TIMP-2和TIMP-1抑制MMP2和MMP9的表达，从而抑制CcRCC的迁移和侵袭。这些结果表明，XRCC1表达降低与ccRCC患者的淋巴转移有关，但不是一个独立的预后因素。XRCC1可作为抑制肾细胞癌转移的潜在治疗靶点，但不能作为独立的预后因素。
X-ray repair cross-complementing group 1 (XRCC1) is a major DNA repair gene that is responsible for fixing DNA base damage and single-strand breaks by interacting with DNA components at the damage site. This study explored the clinical significance of XRCC1 in human clear cell renal cell carcinoma (ccRCC) and further examined the mechanism of the role of XRCC1 in ccRCC. The clinical relevance of XRCC1 in ccRCC was evaluated using tissue microarrays and immunohistochemical staining of two independent human ccRCC cohorts. Our data demonstrated that XRCC1 expression was dramatically decreased in ccRCC tissues compared with that in normal renal tissues and paired adjacent non-tumor tissues. Low XRCC1 expression was significantly correlated with lymph node metastasis and with worse overall and disease-specific survival in patients, as determined by log-rank tests. However, Cox regression analysis revealed that XRCC1 expression was not an independent prognostic factor in ccRCC patients. Furthermore, XRCC1 suppressed ccRCC migration and invasion by inhibiting MMP-2 and MMP-9 expression through the regulation of TIMP-2 and TIMP-1. These findings indicated that decreased XRCC1 expression was associated with lymph node metastasis but was not an independent prognostic factor in ccRCC patients. XRCC1 may serve as a potential therapeutic target for inhibiting ccRCC metastasis but cannot be used as an independent prognostic factor.
登录
查看更多内容
影响因子：
4.6
作者：
Lenglet S;Mach F;Montecucco F
通讯作者：
Montecucco F
RUNX3 抑制人肾细胞癌的迁移、侵袭和血管生成。
影响因子：
3.7
作者：
Chen F;Bai J;Li W;Mei P;Liu H;Li L;Pan Z;Wu Y;Zheng J
通讯作者：
Zheng J
影响因子：
8
作者：
Crnogorac-Jurcevic, T;Efthimiou, E;Lemoine, NR
通讯作者：
Lemoine, NR
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Ward, Elizabeth
通讯作者：
Ward, Elizabeth
影响因子：
--
作者：
Philips N;Auler S;Hugo R;Gonzalez S
通讯作者：
Gonzalez S