Meta-analysis on pharmacogenetics of platinum-based chemotherapy in non small cell lung cancer (NSCLC) patients.
Meta-analysis on pharmacogenetics of platinum-based chemotherapy in non small cell lung cancer (NSCLC) patients.
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DOI：
10.1371/journal.pone.0038150
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Liu ZQ
中科院分区：
文献类型：
--
作者：
Yin JY;Huang Q;Zhao YC;Zhou HH;Liu ZQ
目的：探讨非小细胞肺癌(NSCLC)患者铂为主化疗的药物遗传学。出版物来自PubMed、Cochrane Library和ISI Web of Knowledge。通过检验优势比(OR)和95%可信区间(CI)，进行Meta分析以确定基因多态与以铂为基础的化疗之间的关联。数据来自24篇文献，包括8个基因的11个多态，用于Meta分析。多药耐药基因C3435T(OR = 1.97，95%CI：1.11~3.5 0，P = 0.02)、G2677A/T(OR = 2.61，95%CI：1.44~4.74，P = 0.002)和GSTP1A313G(OR = 0.32，95%CI：0.17~0.58，P = 0.0002)与亚洲非小细胞肺癌患者铂类化疗相关。未来应重视MDR1C3435T、G2677A/T和GSTP1A313G对亚洲人群NSCLC患者的个体化化疗。
To determine the pharmacogenetics of platinum-based chemotherapy in Non Small Cell Lung Cancer (NSCLC) patients. Publications were selected from PubMed, Cochrane Library and ISI Web of Knowledge. A meta-analysis was conducted to determine the association between genetic polymorphisms and platinum-based chemotherapy by checking odds ratio (OR) and 95% confidence interval (CI). Data were extracted from 24 publications, which included 11 polymorphisms in 8 genes for meta-analysis. MDR1 C3435T (OR = 1.97, 95% CI: 1.11–3.50, P = 0.02), G2677A/T (OR = 2.61, 95% CI: 1.44–4.74, P = 0.002) and GSTP1 A313G (OR = 0.32, 95% CI: 0.17–0.58, P = 0.0002) were significantly correlated with platinum-based chemotherapy in Asian NSCLC patients. Attention should be paid to MDR1 C3435T, G2677A/T and GSTP1 A313G for personalized chemotherapy treatment for NSCLC patients in Asian population in the future.
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影响因子：
2.2
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
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作者：
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