Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation.
Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation.
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DOI：
10.3727/096368909788237195
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发表时间：
2009
影响因子：
3.3
通讯作者：
Stupp SI
中科院分区：
文献类型：
--
作者：
Stendahl JC;Kaufman DB;Stupp SI
肝内胰岛移植为胰腺移植提供了一种潜在的更良性的替代方法。然而，胰岛移植与有限的植入潜力有关。这种低效率可能至少部分归因于分离过程，该分离过程将胰岛从其天然环境中移除。分离不仅破坏了胰岛的内部血管化和神经支配，而且从根本上改变了胰岛细胞与细胞外基质（ECM）大分子之间的相互作用。已知胰岛细胞和ECM之间的信号相互作用调节胰岛生理学的多个方面，包括存活、增殖和胰岛素分泌。虽然在隔离期间这些相互作用的中断很可能会显著影响移植结果，但这些条件的真正含义尚未得到很好的理解。以下文章回顾了目前对胰岛-ECM相互作用的理解和不确定性，并解释了其对移植后植入的潜在影响。涵盖的主题包括基质和受体成分在原生胰岛，隔离和文化对胰岛细胞外基质相互作用的影响，以及胰岛细胞外基质相互作用的postisolation恢复的潜力。在这些领域的更多的了解可能有助于减少隔离和移植的压力，提高胰岛移植。
Intrahepatic islet transplantation provides a potentially more benign alternative to pancreatic transplantation. However, islet transplants are associated with limited engraftment potential. This inefficiency is likely at least partially attributable to the isolation process, which removes islets from their native environment. Isolation not only disrupts the internal vascularization and innervation of islets, but also fundamentally changes interactions between islet cells and macromolecules of the extracellular matrix (ECM). Signaling interactions between islet cells and ECM are known to regulate multiple aspects of islet physiology, including survival, proliferation, and insulin secretion. Although it is highly likely that disruptions to these interactions during isolation significantly affect transplant outcomes, the true implications of these conditions are not well understood. The following article reviews current understandings and uncertainties in islet–ECM interactions and explains their potential impact on posttransplant engraftment. Topics covered include matrix and receptor compositions in native islets, effects of isolation and culture on islet–ECM interactions, and potential for postisolation restoration of islet–ECM interactions. Greater understanding in these areas may help to reduce isolation and transplantation stresses and improve islet engraftment.
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影响因子：
5.8
作者：
Carlsson, PO;Palm, F;Mattsson, G
通讯作者：
Mattsson, G
影响因子：
5.8
作者：
Beattie, GM;Cirulli, V;Hayek, A
通讯作者：
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DOI：
10.1073/pnas.97.14.7999
发表时间：
2000-07-05
影响因子：
11.1
作者：
Bonner-Weir, S;Taneja, M;O'Neil, JJ
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影响因子：
3.3
作者：
Edamura, K;Nasu, K;Ohgawara, H
通讯作者：
Ohgawara, H
影响因子：
7.7
作者：
Bosco, D;Meda, P;Rouiller, DG
通讯作者：
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