***ECD*** maternal C-reactive protein as a predictor of neonatal sepsis.
***ECD*** maternal C-reactive protein as a predictor of neonatal sepsis.
复制标题
DOI：
10.1080/13548506.2022.2029503
复制
发表时间：
2024-07
影响因子：
3.8
通讯作者：
Paneth, N.
中科院分区：
文献类型：
--
作者：
Manandhar, J.;Brooks, K.;Samms-Vaughan, M.;Paneth, N.
新生儿全身性细菌感染对新生儿死亡率和发病率有显著影响。非侵入性产前风险标志物可能有助于预测和预防新生儿败血症。我们评估了JAKids妊娠和出生队列研究中婴儿样本中母亲妊娠晚期血清C反应蛋白（CRP）水平与新生儿败血症的相关性。采用基于人群的巢式病例对照设计，从JAKids研究中的婴儿亚组中识别新生儿败血症病例和对照，这些婴儿的母亲在妊娠晚期早期有血清存档，并接受新生儿重症监护。病例为25例新生儿败血症，从医院病历中确定。对照组为62例无败血症新生儿的随机样本，这些新生儿与三个胎龄分层（≤32周、33-36周和≥ 37周）内的病例相匹配。新生儿败血症病例≥ 37周的母亲的母体CRP蛋白的平均水平显著高于对照组的母亲（11.0 mg/dL ± 3.0 vs. 8.7 mg/dL ± 5.9; p <0.05）。在≤ 32周出生的败血症病例中未发现母体CRP差异（9.5 mg/dL ± 4.2 vs 5.8 mg/dL ± 4.0，p = 0.23），在33-36周出生的败血症病例中也未发现母体CRP差异（9.0 mg/dL ± 3.6 vs 11.9 mg/dL ± 7.8，p = 0.34）。足月新生儿败血症的母亲妊娠晚期C反应蛋白水平升高，但早产新生儿败血症的母亲妊娠晚期C反应蛋白水平升高。
Systemic bacterial infection in the newborn has a significant impact on neonatal mortality and morbidity. Non-invasive prenatal markers of risk could be useful in the prediction and prevention of neonatal sepsis. We evaluated the association of maternal third-trimester serum level of C-Reactive Protein (CRP) with neonatal sepsis in a sample of infants in the JAKids pregnancy and birth cohort study. A population-based nested case-control design was used to identify cases and controls of neonatal sepsis from the subset of infants in the JAKids study whose mothers had serum archived in the early third trimester and who were admitted to newborn intensive care. Cases were 25 neonates with neonatal sepsis identified from hospital records. Controls were a random sample of 62 sepsis-free neonates matched to cases within three gestational age strata - ≤32 weeks, 33–36 weeks, and ≥ 37 weeks. Mothers of neonatal sepsis cases ≥ 37 weeks had significantly higher mean levels of maternal CRP protein than mothers of controls (11.0 mg/dL ± 3.0 vs. 8.7 mg/dL ± 5.9; p < .05). Differences in maternal CRP were not found in sepsis cases born ≤ 32 weeks (9.5 mg/dL ± 4.2 vs 5.8 mg/dL ± 4.0, p =.23) nor in sepsis cases born at 33–36 weeks (9.0mg/dL ± 3.6 vs 11.9mg/dL ± 7.8, p =.34). Maternal third-trimester C-reactive protein levels were elevated in mothers of term-born neonates with sepsis, but not in the mothers of preterm neonates with sepsis.
登录
查看更多内容
影响因子：
2.9
作者：
Su, H.;Chang, S-S;Lee, C-C
通讯作者：
Lee, C-C
影响因子：
2.3
作者：
Trabert, Britton;Longnecker, Matthew P.;McGlynn, Katherine A.
通讯作者：
McGlynn, Katherine A.
影响因子：
168.9
作者：
Liu, Li;Johnson, Hope L.;Black, Robert E.
通讯作者：
Black, Robert E.
影响因子：
2.4
作者：
Jeon, Ji Hyun;Namgung, Ran;Lee, Chul
通讯作者：
Lee, Chul
影响因子：
28.2
作者：
Shane, Andi L.;Stoll, Barbara J.
通讯作者：
Stoll, Barbara J.