Anosmin1 Shuttles Fgf to Facilitate Its Diffusion, Increase Its Local Concentration, and Induce Sensory Organs.
Anosmin1 Shuttles Fgf to Facilitate Its Diffusion, Increase Its Local Concentration, and Induce Sensory Organs.
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Anosmin1 穿梭 Fgf 以促进其扩散，增加其局部浓度，并诱导感觉器官。
DOI：
10.1016/j.devcel.2018.07.015
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发表时间：
2018
影响因子：
11.8
通讯作者：
Knaut,Holger
中科院分区：
文献类型：
--
作者：
Wang,John;Yin,Yandong;Lau,Stephanie;Sankaran,Jagadish;Rothenberg,Eli;Wohland,Thorsten;Meier-Schellersheim,Martin;Knaut,Holger
Growth factors induce and pattern sensory organs, but how their distribution is regulated by the extracellular matrix (ECM) is largely unclear. To address this question, we analyzed the diffusion behavior of Fgf10 molecules during sensory organ formation in the zebrafish posterior lateral line primordium. In this tissue, secreted Fgf10 induces organ formation at a distance from its source. We find that most Fgf10 molecules are highly diffusive and move rapidly through the ECM. We identify Anosmin1, which when mutated in humans causes Kallmann Syndrome, as an ECM protein that binds to Fgf10 and facilitates its diffusivity by increasing the pool of fast-moving Fgf10 molecules. In the absence of Anosmin1, Fgf10 levels are reduced and organ formation is impaired. Global overexpression of Anosmin1 slows the fast-moving Fgf10 molecules and results in Fgf10 dispersal. These results suggest that Anosmin1 liberates ECM-bound Fgf10 and shuttles it to increase its signaling range.
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影响因子：
--
作者：
Molina GA;Watkins SC;Tsang M
通讯作者：
Tsang M
影响因子：
7.2
作者：
Belov AA;Mohammadi M
通讯作者：
Mohammadi M
基因表达模式 X 染色体连锁卡尔曼综合征背后的 KAL-1 基因的两个 zebra ® 短直系同源物的表征
DOI：
--
发表时间：
1999
期刊：
影响因子：
--
作者：
Olivier Ardouina;Renaud Legouisa;Laurent Fasanob;Brigitte David;Henri Kornc;Jean;Christine Petita
通讯作者：
Christine Petita
影响因子：
11.8
作者：
Kok, Fatma O.;Shin, Masahiro;Ni, Chih-Wen;Gupta, Ankit;Grosse, Ann S.;van Impel, Andreas;Kirchmaier, Bettina C.;Peterson-Maduro, Josi;Kourkoulis, George;Male, Ira;DeSantis, Dana F.;Sheppard-Tindell, Sarah;Ebarasi, Lwaki;Betsholtz, Christer;Schulte-Merker, Stefan;Wolfe, Scot A.;Lawson, Nathan D.
通讯作者：
Lawson, Nathan D.
影响因子：
11.8
作者：
Aman, Andy;Piotrowski, Tatjana
通讯作者：
Piotrowski, Tatjana