Lifestyle modifications with anti-neuroinflammatory benefits in the aging population.
Lifestyle modifications with anti-neuroinflammatory benefits in the aging population.
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DOI：
10.1016/j.exger.2020.111144
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发表时间：
2020-12
影响因子：
3.9
通讯作者：
Barrientos RM
中科院分区：
文献类型：
--
作者：
Muscat SM;Barrientos RM
与衰老相关的小胶质细胞启动可能导致对大脑中支持学习和记忆的区域中随后的炎症挑战做出夸大的神经炎性反应。这种过度的神经炎症在老化的大脑中发生，已知发生在各种外周侮辱之后，包括感染和手术，在这些情况下，它与认知和记忆的急剧下降有关。随着全球平均寿命的延长，确定预防和治疗与衰老相关的过度神经炎症和随之而来的认知障碍的干预措施至关重要。在这一努力中，生活方式已成为潜在的非药理学目标。在这里，我们回顾了重要的和最新的临床前和临床文献，展示了在衰老和记忆的背景下，生活方式改变的抗炎作用，如运动、饮食和丰富的环境。重要的是，我们专注于研究表明，这些生活方式的改变不需要是终生的，这表明这种干预在预防和治疗与衰老和神经炎症相关的认知障碍方面可能是有效的，即使是在老年人开始的时候。
Aging-associated microglial priming results in the potential for an exaggerated neuroinflammatory response to a subsequent inflammatory challenge in regions of the brain known to support learning and memory. This excessive neuroinflammation in the aging brain is known to occur following a variety of peripheral insults, including infection and surgery, where it has been associated with precipitous declines in cognition and memory. As the average lifespan increases worldwide, identifying interventions to prevent and treat aging-associated excessive neuroinflammation and ensuing cognitive impairments is of critical importance. Lifestyle has emerged as a potential non-pharmacological target in this endeavor. Here, we review important and recent preclinical and clinical literature demonstrating the anti-inflammatory effects of lifestyle modifications such as exercise, diet, and environmental enrichment in the context of aging and memory. Importantly, we focus on research indicating that these lifestyle modifications do not need to be lifelong, suggesting that such interventions may be efficacious in the prevention and treatment of aging- and neuroinflammation-associated cognitive impairment, even when initiated in older age.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
DOI：
10.1523/jneurosci.2173-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barrientos RM;Hein AM;Frank MG;Watkins LR;Maier SF
通讯作者：
Maier SF
影响因子：
5.3
作者：
Cavaliere, Gina;Trinchese, Giovanna;Mollica, Maria Pina
通讯作者：
Mollica, Maria Pina
影响因子：
5.4
作者：
Cherrie, Mark P. C.;Shortt, Niamh K.;Pearce, Jamie R.
通讯作者：
Pearce, Jamie R.
影响因子：
5.2
作者：
Ali, Seemaab;Liu, Xianglan;Cao, Lei
通讯作者：
Cao, Lei