Long-term changes in reward-seeking following morphine withdrawal are associated with altered N-methyl-D-aspartate receptor 1 splice variants in the amygdala.
Long-term changes in reward-seeking following morphine withdrawal are associated with altered N-methyl-D-aspartate receptor 1 splice variants in the amygdala.
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DOI：
10.1016/j.neuroscience.2012.07.037
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发表时间：
2012-10-25
期刊：
影响因子：
3.3
通讯作者：
Caudle, R. M.
中科院分区：
文献类型：
--
作者：
Anderson, E. M.;Neubert, J. K.;Caudle, R. M.
NMDA受体的NR 1亚基可以通过插入或去除N1、C1、C2或C2′区域进行选择性剪接。先前的研究表明，吗啡依赖和戒断会降低杏仁核中的N1和C2′，降低杏仁核中的N1、C1和C2′。戒断也被证明会增加大鼠的动机和焦虑/压力行为。我们在两个月的延长停药期内测试了NR 1剪接与这些行为相关的假设。在非厌恶性温度（37°C）下使用操作性口面分析来测量动机，而通过在厌恶性温度（46°C）下检查这种行为来测量焦虑和压力。即使在吗啡戒断两个月后，在戒断大鼠的一个亚组中观察到杏仁核中C1和C2的表达水平较低。这些亚组与对不良状况的超敏反应相关，这可能反映了退出人群的长期变化。
The NR1 subunit of the NMDA receptor can be alternatively spliced by the insertion or removal of the N1, C1, C2, or C2′ regions. Morphine dependence and withdrawal were previously demonstrated to lower N1 and C2′ in the accumbens and lower N1, C1, and C2′ in the amygdala. Withdrawal has also been demonstrated to increase motivational and anxiety/stress behaviors in rats. We tested the hypothesis that NR1 splicing would be associated with these behaviors during an extended withdrawal period of two months. Motivation was measured using an operant orofacial assay at non-aversive temperatures (37°C) while anxiety and stress were measured by examining this behavior at aversive temperatures (46°C). Lower C1 and C2 expression levels were observed in the amygdala in a subset of the population of withdrawn rats even after two months of morphine withdrawal. These subsets were associated with a hypersensitivity to adverse conditions which may reflect long-term alterations in the withdrawn population.
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影响因子：
3.3
作者：
Anderson, E. M.;Del Valle-Pinero, A. Y.;Suckow, S. K.;Nolan, T. A.;Neubert, J. K.;Caudle, R. M.
通讯作者：
Caudle, R. M.
成瘾和大脑奖励和反发达途径。
影响因子：
--
作者：
Gardner EL
通讯作者：
Gardner EL
影响因子：
3.3
作者：
Glass, M. J.;Vanyo, L.;Quimson, L.;Pickel, V. M.
通讯作者：
Pickel, V. M.
影响因子：
3.5
作者：
Gaunitz, C;Schüttler, A;Allgaier, C
通讯作者：
Allgaier, C
影响因子：
5
作者：
Avila, Milton A. V.;Ruggiero, Rafael N.;Castilho, Vanessa M.
通讯作者：
Castilho, Vanessa M.