The arrestin fold: variations on a theme.
The arrestin fold: variations on a theme.
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DOI：
10.2174/138920209787847014
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发表时间：
2009-04
期刊：
影响因子：
2.6
通讯作者：
Klein G
中科院分区：
文献类型：
--
作者：
Aubry L;Guetta D;Klein G
配体激活的质膜受体的内吞作用已被证明有助于调节其下游信号传导。β-抑制蛋白与活化受体的磷酸化尾部相互作用，并充当募集衔接蛋白和网格蛋白的支架，衔接蛋白和网格蛋白构成用于受体内吞作用的机制。视觉抑制蛋白和β-抑制蛋白具有两叶、免疫球蛋白样β链夹心结构。最近的决议的晶体结构的VPS 26，retromer亚基之一，出乎意料地证明了一个arrestin折叠在这种蛋白质，这是无关的arrestins。从功能的角度来看，VPS 26参与甘露糖6-P受体从内体到高尔基体网络的逆行转运。除了真正的抑制蛋白和Vps 26之外，哺乳动物细胞还具有大量基于其PFAMNter和Cter抑制蛋白结构域与抑制蛋白相关的蛋白质，称为含抑制蛋白结构域的蛋白质（ADC）. ADC蛋白的生物学作用仍然知之甚少。这三个亚家族已经合并成一个抑制蛋白相关蛋白家族。本文提供了一个全面的分析arrestin族蛋白。综述了哺乳动物和模式生物如果蝇、小杆线虫、酵母菌和网骨藻中各亚家族成员的结构和功能。
Endocytosis of ligand-activated plasma membrane receptors has been shown to contribute to the regulation of their downstream signaling. β-arrestins interact with the phosphorylated tail of activated receptors and act as scaffolds for the recruitment of adaptor proteins and clathrin, that constitute the machinery used for receptor endocytosis. Visual- and β-arrestins have a two-lobe, immunoglobulin-like, β-strand sandwich structure. The recent resolution of the crystal structure of VPS26, one of the retromer subunits, unexpectedly evidences an arrestin fold in this protein, which is otherwise unrelated to arrestins. From a functional point of view, VPS26 is involved in the retrograde transport of the mannose 6-P receptor from the endosomes to the trans-Golgi network. In addition to the group of genuine arrestins and Vps26, mammalian cells harbor a vast repertoire of proteins that are related to arrestins on the basis of their PFAM Nter and Cter arrestin- domains, which are named Arrestin Domain- Containing proteins (ADCs). The biological role of ADC proteins is still poorly understood. The three subfamilies have been merged into an arrestin-related protein clan. This paper provides an overall analysis of arrestin clan proteins. The structures and functions of members of the subfamilies are reviewed in mammals and model organisms such as Drosophila, Caenorhabditis, Saccharomyces and Dictyostelium.
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影响因子：
4.5
作者：
Burtey, Anne;Schmid, Eva M.;Benmerah, Alexandre
通讯作者：
Benmerah, Alexandre
DOI：
10.1016/0167-4781(94)90242-9
发表时间：
1994-09-13
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
影响因子：
--
作者：
CHEN, KS;DELUCA, HF
通讯作者：
DELUCA, HF
影响因子：
64.8
作者：
Granzin, J;Wilden, U;Büldt, G
通讯作者：
Büldt, G
影响因子：
14.9
作者：
Dereeper A;Guignon V;Blanc G;Audic S;Buffet S;Chevenet F;Dufayard JF;Guindon S;Lefort V;Lescot M;Claverie JM;Gascuel O
通讯作者：
Gascuel O
影响因子：
14.9
作者：
Chenna, R;Sugawara, H;Thompson, JD
通讯作者：
Thompson, JD