An Overview of the Medicinally Important Plant Type III PKS Derived Polyketides.
An Overview of the Medicinally Important Plant Type III PKS Derived Polyketides.
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DOI：
10.3389/fpls.2021.746908
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发表时间：
2021
影响因子：
5.6
通讯作者：
Saxena P
中科院分区：
文献类型：
--
作者：
Bisht R;Bhattacharyya A;Shrivastava A;Saxena P
植物产生有趣的次级代谢产物，是人类使用的两种药物的宝贵来源，沿着对制造商物种具有显着优势。导致这些工具效应的活性化合物通常是在植物生长的各个阶段产生的次级代谢产物，其提供宿主生存优势，同时无意中影响人类健康。不同化学类别的次级代谢产物由植物III型聚酮酶（PKS）生物合成。它们是简单的同源二聚体蛋白，具有独特的机械潜力，通过利用更简单的起始剂和扩展剂单元产生广泛的次级代谢产物。这些PKS衍生的产物主要是一些重要的次级代谢途径的前体，这些次级代谢途径导致诸如类黄酮、芪、苄叉丙酮、色酮、吖啶酮、氧杂蒽酮、大麻素、脂肪族蜡、生物碱、蒽酮和吡喃酮的产物。这些次级代谢产物具有各种制药、医药和工业应用，这使得生物合成III型PKS成为生物工程目的的重要工具。由于它们的结构简单和易于操作，这些酶近年来由于它们在非天然天然聚酮化合物和修饰产物的产生中的应用而引起了人们的兴趣，以寻找用于各种健康问题的新药。以下综述涵盖了各种III型PKS衍生的次级代谢产物的生物合成，其生物学相关性，相关酶，以及最近的研究。
Plants produce interesting secondary metabolites that are a valuable source of both medicines for human use, along with significant advantages for the manufacturer species. The active compounds which lead to these instrumental effects are generally secondary metabolites produced during various plant growth phases, which provide the host survival advantages while affecting human health inadvertently. Different chemical classes of secondary metabolites are biosynthesized by the plant type III polyketide synthases (PKSs). They are simple homodimeric proteins with the unique mechanistic potential to produce a broad array of secondary metabolites by utilizing simpler starter and extender units. These PKS derived products are majorly the precursors of some important secondary metabolite pathways leading to products such as flavonoids, stilbenes, benzalacetones, chromones, acridones, xanthones, cannabinoids, aliphatic waxes, alkaloids, anthrones, and pyrones. These secondary metabolites have various pharmaceutical, medicinal and industrial applications which make biosynthesizing type III PKSs an important tool for bioengineering purposes. Because of their structural simplicity and ease of manipulation, these enzymes have garnered interest in recent years due to their application in the generation of unnatural natural polyketides and modified products in the search for newer drugs for a variety of health problems. The following review covers the biosynthesis of a variety of type III PKS-derived secondary metabolites, their biological relevance, the associated enzymes, and recent research.
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影响因子：
15
作者：
Abe, I;Utsumi, Y;Noguchi, H
通讯作者：
Noguchi, H
DOI：
10.1046/j.1432-1327.2001.02255.x
发表时间：
2001-06-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
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作者：
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通讯作者：
Noguchi, H
DOI：
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发表时间：
2011-09
期刊：
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影响因子：
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作者：
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通讯作者：
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影响因子：
11.6
作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
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作者：
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通讯作者：
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