Transmission of Zearalenone, Deoxynivalenol, and Their Derivatives from Sows to Piglets during Lactation.
Transmission of Zearalenone, Deoxynivalenol, and Their Derivatives from Sows to Piglets during Lactation.
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DOI：
10.3390/toxins13010037
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发表时间：
2021-01-06
期刊：
影响因子：
4.2
通讯作者：
Santos RR
中科院分区：
文献类型：
--
作者：
Benthem de Grave X;Saltzmann J;Laurain J;Rodriguez MA;Molist F;Dänicke S;Santos RR
母猪饲喂含有以下成分的天然污染饲料：（i）分娩前一周和哺乳期（第26天）100 ppb玉米赤霉烯酮（ZEN），（ii）分娩前一周100 ppb ZEN和哺乳期300 ppb ZEN，或（iii）分娩前一周和哺乳期300 ppb ZEN。所有的饮食含有250 ppb脱氧雪腐镰刀菌烯醇（DON）。在分娩前和哺乳期间饲喂300 ppb ZEN的母猪血清中观察到ZEN、α-ZEL或β-ZEL的最高水平。然而，这些母猪的初乳和乳汁中仅α-ZEL显著增加。在整个试验期间饲喂300 ppb ZEN的母猪在分娩前出现背膘厚度显著降低。这种作用伴随着血清瘦素水平的降低。这些母猪还表现出雌二醇水平降低，并且在哺乳期暴露的仔猪中观察到该效应，其表现出胰高血糖素样肽1增加，但血清ZEN、α-ZEL或β-ZEL水平无变化。虽然所有母猪饲喂相同水平的DON，但在整个实验期间，DON和de-epoxy-DON的血清水平仅在来自饲喂具有最高ZEN水平的饮食的母猪的仔猪的血清中增加。此外，这些仔猪表现出肠道炎症，如其血清中钙卫蛋白水平显著增加所示。
Sows were fed naturally contaminated diets containing: (i) 100 ppb zearalenone (ZEN) one week before farrowing and during the lactation period (at 26 days), (ii) 100 ppb ZEN one week before farrowing and 300 ppb ZEN during the lactation period, or (iii) 300 ppb ZEN one week before farrowing and during the lactation period. All diets contained 250 ppb deoxynivalenol (DON). The highest levels of ZEN, α-ZEL, or β-ZEL were observed in the serum of sows fed 300 ppb ZEN before farrowing and during lactation. However, only α-ZEL was significantly increased in the colostrum and milk of these sows. Sows fed the 300 ppb ZEN during the complete trial presented a significant decrease in backfat thickness before farrowing. This effect was accompanied by a decrease in serum leptin levels. These sows also presented a decrease in estradiol levels and this effect was observed in their piglets exposed during lactation, which presented increased glucagon-like peptide 1, but no changes in serum levels of ZEN, α-ZEL, or β-ZEL. Although all sows were fed the same levels of DON, the serum levels of DON and de-epoxy-DON were increased only in the serum of piglets from the sows fed a diet with the highest ZEN levels during the whole experimental period. Moreover, these piglets presented gut inflammation, as indicated by significantly increased calprotectin levels in their serum.
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高水平脱氧雪腐镰刀菌烯醇和玉米赤霉烯酮对猪生长性能以及血液学和免疫学参数的影响。
影响因子：
4.2
作者：
Reddy KE;Song J;Lee HJ;Kim M;Kim DW;Jung HJ;Kim B;Lee Y;Yu D;Kim DW;Oh YK;Lee SD
通讯作者：
Lee SD
影响因子：
2.2
作者：
Reddy KE;Kim M;Kim KH;Ji SY;Baek Y;Chun JL;Jung HJ;Choe C;Lee HJ;Kim M;Lee SD
通讯作者：
Lee SD
DOI：
10.1080/02652030600988038
发表时间：
2007-04-01
影响因子：
2.9
作者：
Goyarts, Tanja;Daenicke, Sven;Ueberschaer, Karl-Heinz
通讯作者：
Ueberschaer, Karl-Heinz
影响因子：
4.2
作者：
Marin DE;Motiu M;Taranu I
通讯作者：
Taranu I
影响因子：
3.3
作者：
LONG, GG;DIEKMAN, MA
通讯作者：
DIEKMAN, MA