Spectroscopy-based multi-parametric quantification in subjects with liver iron overload at 1.5T and 3T.
Spectroscopy-based multi-parametric quantification in subjects with liver iron overload at 1.5T and 3T.
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DOI：
10.1002/mrm.29021
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发表时间：
2022-03
影响因子：
3.3
通讯作者：
Hernando D
中科院分区：
文献类型：
--
作者：
Simchick G;Zhao R;Hamilton G;Reeder SB;Hernando D
评价定量刺激回波采集模式（STEAM-）磁共振波谱（MRS）的精密度（重复性和再现性），并确定1.5T和3 T下铁过载受试者中慢性肝病（CLD）的多种MR生物标志物之间的关系。在已知或疑似肝铁超载的患者中采集MRS数据。在1.5T和3 T（同一天）下采集两个STEAM-MRS序列（多TE和多TE-TR），包括重测采集。每次采集都可以估计半峰全宽（FWHM）、R1和R2（分别针对水和脂肪）以及质子密度脂肪分数（PDFF）。使用组内相关系数（ICC）、线性回归和Bland-Altman分析评价了估计值在不同采集模式（多TE与多TE-TR）下的重测重复性和再现性。还使用线性和非线性回归评价了每个场强、跨场强和肝脏铁浓度（LIC）下参数之间的多参数关系。成功招募了五十六例（n=56）受试者（10-73岁，37例男性/19例女性）。在1.5T和3 T下，两种STEAM-MRS序列对R1水、R2水、FWHM水和PDFF的定量均表现出良好至极好的精密度（ICC ≥ 0.81）。此外，在生物标志物之间、不同场强之间以及与LIC之间观察到几种中度（R2 = 0.50 - 0.69）至高度（R2 ≥ 0.70）相关性。在广泛的LIC范围内，STEAM-MRS能够快速精确地测量CLD的多种生物标志物。通过评估生物标志物之间的多参数关系，这项工作可能会推进基于MRS的CLD综合评估，并可能有助于建立CLD的生物标志物。
To evaluate the precision profile (repeatability and reproducibility) of quantitative stimulated-echo acquisition mode (STEAM-) magnetic resonance spectroscopy (MRS) and to determine the relationships between multiple MR biomarkers of chronic liver disease (CLD) in subjects with iron overload at both 1.5T and 3T. MRS data were acquired in patients with known or suspected liver iron overload. Two STEAM-MRS sequences (multi-TE and multi-TE-TR) were acquired at both 1.5T and 3T (same day), including test-retest acquisition. Each acquisition enabled estimation of full-width at half-maximum (FWHM), R1, and R2 (each separately for water and fat), and proton density fat fraction (PDFF). The test-retest repeatability and reproducibility across acquisition modes (multi-TE vs multi-TE-TR) of the estimates were evaluated using intraclass correlation coefficients (ICC), linear regression, and Bland-Altman analyses. Multi-parametric relationships between parameters at each field strength, across field strengths, and with liver iron concentration (LIC) were also evaluated using linear and nonlinear regression. Fifty-six (n=56) subjects (10-73 years, 37M/19F) were successfully recruited. Both STEAM-MRS sequences demonstrated good to excellent precision (ICC ≥ 0.81) for the quantification of R1water, R2water, FWHMwater, and PDFF at both 1.5T and 3T. Additionally, several moderate (R2 = 0.50 – 0.69) to high (R2 ≥ 0.70) correlations were observed between biomarkers, across field strengths, and with LIC. Over a broad range of LIC, STEAM-MRS enables rapid and precise measurement of multiple biomarkers of CLD. By evaluating the multi-parametric relationships between biomarkers, this work may advance the comprehensive MRS-based assessment of CLD and may help establish biomarkers of CLD.
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影响因子：
4.4
作者：
Horng, Debra E.;Hernando, Diego;Hines, Catherine D. G.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
DOI：
10.1002/jmri.26312
发表时间：
2019-05
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Bashir MR;Wolfson T;Gamst AC;Fowler KJ;Ohliger M;Shah SN;Alazraki A;Trout AT;Behling C;Allende DS;Loomba R;Sanyal A;Schwimmer J;Lavine JE;Shen W;Tonascia J;Van Natta ML;Mamidipalli A;Hooker J;Kowdley KV;Middleton MS;Sirlin CB;NASH Clinical Research Network (NASH CRN)
通讯作者：
NASH Clinical Research Network (NASH CRN)
影响因子：
3.3
作者：
Hernando, Diego;Liang, Zhi-Pei;Kellman, Peter
通讯作者：
Kellman, Peter
影响因子：
3.8
作者：
Ballestri S;Nascimbeni F;Baldelli E;Marrazzo A;Romagnoli D;Lonardo A
通讯作者：
Lonardo A
影响因子：
4.4
作者：
Hernando, Diego;Levin, Yakir S.;Sirlin, Claude B.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.