Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy.

Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy.
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DOI:
10.1016/j.pcad.2021.04.001
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发表时间:
2021-05
影响因子:
9.1
通讯作者:
Ellenbogen, Kenneth A.
Ellenbogen, Kenneth A.
中科院分区:
医学2区
文献类型:
--
作者:
Huizar, Jose F.;Tan, Alex Y.;Kaszala, Karoly;Ellenbogen, Kenneth A.

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医学界对室性早搏(PVC)和PVC诱导的心肌病后果的理解主要来自观察性和大规模人群研究。由于难以预测PVC-心肌病的发展,PVC的急性和慢性心脏效应以及PVC-心肌病的机制来自大型动物模型的临床前研究。最近,这些研究描述了心肌基质可能增加频繁PVC和PVC心肌病患者的发病率和死亡率。在本文中,我们提供了一个最新的全面审查这些临床前和临床研究。
The medical community’s understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been derived from pre-clinical studies with large animal models. Recently, these studies have described myocardial substrates that could potentially increase morbidity and mortality in patients with frequent PVCs and PVC-cardiomyopathy. In this paper, we provide an up-to-date comprehensive review of these pre-clinical and clinical studies.
心室过早复合物与心力衰竭的关系(来自社区的动脉粥样硬化风险[ARIC]研究)。
DOI: 10.1016/j.amjcard.2011.08.009
发表时间: 2012-01-01
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