Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy.
Clinical and translational insights on premature ventricular contractions and PVC-induced cardiomyopathy.
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DOI:
10.1016/j.pcad.2021.04.001
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发表时间:
2021-05
影响因子:
9.1
通讯作者:
Ellenbogen, Kenneth A.
中科院分区:
文献类型:
--
作者:
Huizar, Jose F.;Tan, Alex Y.;Kaszala, Karoly;Ellenbogen, Kenneth A.
关键词:
The medical community’s understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been derived from pre-clinical studies with large animal models. Recently, these studies have described myocardial substrates that could potentially increase morbidity and mortality in patients with frequent PVCs and PVC-cardiomyopathy. In this paper, we provide an up-to-date comprehensive review of these pre-clinical and clinical studies.
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