Relation of ventricular premature complexes to heart failure (from the Atherosclerosis Risk In Communities [ARIC] Study).
Relation of ventricular premature complexes to heart failure (from the Atherosclerosis Risk In Communities [ARIC] Study).
复制标题
心室过早复合物与心力衰竭的关系（来自社区的动脉粥样硬化风险[ARIC]研究）。
DOI：
10.1016/j.amjcard.2011.08.009
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Heiss, Gerardo
中科院分区：
文献类型：
--
作者：
Agarwal, Sunil K.;Simpson, Ross J., Jr.;Rautaharju, Pentti;Alonso, Alvaro;Shahar, Eyal;Massing, Mark;Saba, Samir;Heiss, Gerardo
与快速心室起搏类似，频繁的室性早搏复合波（VPC）可能随着时间的推移而易患心肌病和随后的心力衰竭（HF）。我们在一个基于人群的队列中研究了频繁的VPC与HF发病率的关系，基线时无HF和冠心病（CHD）。在研究基线（1987-89年）时，在ARIC队列的5.5%（739/13486）的中年（基线时45-64岁）、白色和非洲裔美国人男性和女性中观察到至少1例2分钟节律ECG条上的VPC。HF事件定义为直到2005年在出院记录或死亡证明中首次出现ICD代码“428.x”。在平均15.6年的随访中，10%的受试者发生了HF事件（有VPC的受试者为19.4%，无VPC的受试者为9.4%）。VPC的HF经年龄、人种和性别校正的风险比（HR）为1.89（95% CI = 1.59，2.24）。在对潜在混杂因素进行多变量校正后，有任何VPC的患者与无VPC的患者的HF HR（95% CI）为1.63（1.36，1.96）。将CHD事件作为时变协变量进行额外校正后，HR（95% CI）为1.71（1.42，2.08）。高频率VPC或复杂VPC的HF发生率与单一VPC组相似，均高于无VPC组。总之，在这个基于大人群的队列中，VPC的存在与HF事件相关，与CHD事件无关。
Analogous to rapid ventricular pacing, frequent ventricular premature complexes (VPCs) may predispose over time to cardiomyopathy and subsequent heart failure (HF). We examined the association of frequent VPCs with HF incidence in a population-based cohort, free of HF and coronary heart disease (CHD) at baseline. At study baseline (1987-89), at least one VPC on a 2-minute rhythm ECG strip was seen in 5.5% (739/13486) of the middle aged (45-64 years old at baseline), white and African-American, men and women of the ARIC cohort. Incident HF was defined as the first appearance of ICD code ‘428.x’ in hospital discharge record or death certificate through 2005. Over an average follow up of 15.6 years, incident HF was seen in 10% subjects (19.4% in those with VPCs vs. 9.4% in those without). The age, race, and gender adjusted hazard ratio (HR) of HF for VPCs was 1.89 (95% CI = 1.59, 2.24). After multivariable adjustment for potential confounders, HR (95% CI) of HF for those with any VPC vs. no VPCs was 1.63 (1.36, 1.96). After additional adjustment for incident CHD as a time-varying covariate, the HR (95% CI) was 1.71 (1.42, 2.08). Presence of higher frequency of VPCs or complex VPCs had similar rates of HF as compared to single VPC and all were higher than no VPC group. In conclusion, in this large population based cohort, presence of VPCs is associated with incident HF independent of incident CHD.
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DOI：
10.1111/j.1540-8167.2008.01317.x
发表时间：
2009-03-01
影响因子：
2.7
作者：
Markowitz, Steven M.;Lewen, Jason M.;Lerman, Bruce B.
通讯作者：
Lerman, Bruce B.
影响因子：
1.5
作者：
Topaloglu, Serkan;Aras, Dursun;Korkmaz, Sule
通讯作者：
Korkmaz, Sule
影响因子：
4.8
作者：
Simpson, RJ;Cascio, WE;Heiss, G
通讯作者：
Heiss, G
DOI：
10.1038/ncpcardio1180
发表时间：
2008-05-01
期刊：
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
影响因子：
--
作者：
Ezzat, Vivienne A.;Liew, Reginald;Ward, David E.
通讯作者：
Ward, David E.
影响因子：
4.8
作者：
Shahar, E;Folsom, AR;Heiss, G
通讯作者：
Heiss, G