Urinary F2-isoprostanes and metabolic markers of fat oxidation.
Urinary F2-isoprostanes and metabolic markers of fat oxidation.
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DOI：
10.1155/2015/729191
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发表时间：
2015
影响因子：
--
通讯作者：
D'Agostino RB Jr
中科院分区：
文献类型：
--
作者：
Il'yasova D;Wagenknecht LE;Spasojevic I;Watkins S;Bowden D;Wang F;D'Agostino RB Jr
脂肪氧化增加的代谢组学研究显示，循环酰基肉毒碱C2、C8、C10和C12增加，C3、C4和C5减少。我们假设尿F2-异前列腺素反映了脂肪酸氧化的强度，与循环C2、C8、C10和C12直接相关，与C3、C4和C5反向相关。在胰岛素抵抗动脉粥样硬化研究非糖尿病组群（n = 682）中，使用LC-MS/MS定量四种尿F2-异前列烷异构体和血清酰基肉毒碱。空腹尿F2-异前列腺素（总结为一个复合指数）和选定的酰基肉毒碱之间的横截面关联进行检查，使用广义线性模型。F2-异前列腺素指数与C2和C12直接相关，与C5反向相关：调整后的β系数分别为0.109、0.072和-0.094（P < 0.05）。对于这些酰基肉毒碱和F2-异前列腺素，根据逻辑回归模型计算糖尿病事件的调整优势比（OR）：C2、C12、C5和F2-异前列烷的OR（95%CI）分别为0.77（0.60-0.97）、0.79（0.62 -1.01）、1.18（0.92-1.53）和0.51（0.35-0.76）。尿F2-异前列烷和三个酰基肉毒碱（C2，C5和C12）之间的关联的方向支持我们的假设。C2和C12与糖尿病发病率的负相关性与有效脂肪氧化的保护作用一致。
Metabolomic studies of increased fat oxidation showed increase in circulating acylcarnitines C2, C8, C10, and C12 and decrease in C3, C4, and C5. We hypothesize that urinary F2-isoprostanes reflect intensity of fatty acid oxidation and are associated with circulating C2, C8, C10, and C12 directly and with C3, C4, and C5 inversely. Four urinary F2-isoprostane isomers and serum acylcarnitines are quantified using LC-MS/MS within the Insulin Resistance Atherosclerosis Study nondiabetic cohort (n = 682). Cross-sectional associations between fasting urinary F2-isoprostanes (summarized as a composite index) and the selected acylcarnitines are examined using generalized linear models. F2-isoprostane index is associated with C2 and C12 directly and with C5 inversely: the adjusted beta coefficients are 0.109, 0.072, and −0.094, respectively (P < 0.05). For these acylcarnitines and for F2-isoprostanes, the adjusted odds ratios (ORs) of incident diabetes are calculated from logistic regression models: the ORs (95% CI) are 0.77 (0.60–0.97), 0.79 (0.62–1.01), 1.18 (0.92–1.53), and 0.51 (0.35–0.76) for C2, C12, C5, and F2-isoprostanes, respectively. The direction of the associations between urinary F2-isoprostanes and three acylcarnitines (C2, C5, and C12) supports our hypothesis. The inverse associations of C2 and C12 and with incident diabetes are consistent with the suggested protective role of efficient fat oxidation.
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影响因子：
--
作者：
HOPPEL, CL;GENUTH, SM
通讯作者：
GENUTH, SM
影响因子：
3.7
作者：
Lehmann R;Zhao X;Weigert C;Simon P;Fehrenbach E;Fritsche J;Machann J;Schick F;Wang J;Hoene M;Schleicher ED;Häring HU;Xu G;Niess AM
通讯作者：
Niess AM
影响因子：
11.4
作者：
Quinlan CL;Perevoshchikova IV;Hey-Mogensen M;Orr AL;Brand MD
通讯作者：
Brand MD
DOI：
10.1016/j.cca.2012.06.012
发表时间：
2012-10-09
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Il'yasova D;Scarbrough P;Spasojevic I
通讯作者：
Spasojevic I
影响因子：
4.9
作者：
Heilbronn, L;Smith, SR;Ravussin, E
通讯作者：
Ravussin, E