Reassessment of the function of somatolactin alpha in lipid metabolism using medaka mutant and transgenic strains.
Reassessment of the function of somatolactin alpha in lipid metabolism using medaka mutant and transgenic strains.
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DOI：
10.1186/1471-2156-13-64
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发表时间：
2012-07-24
期刊：
影响因子：
2.9
通讯作者：
Fukamachi S
中科院分区：
文献类型：
--
作者：
Sasano Y;Yoshimura A;Fukamachi S
生长激素α（SLa）是一种鱼类特有的肽类激素，由脑垂体分泌。在青少年中，SLa的功能是使肤色变暗，缺乏SLa会使肤色变白。当鱼分别保持在黑暗或明亮的条件下，SLa的转录增强或抑制，表明SLa的重要作用，在背景驯化的肤色。然而，奇怪的是，SLa的缺乏似乎会导致器官中甘油三酯增加的额外缺陷，这不能通过其过度表达来挽救（减少）。为了评估这一神秘的结果，我们研究了遗传（SLa，Slc 45 a2，r和Y基因）和非遗传（年龄，禁食，水温和背景颜色）对肝脏甘油三酯的影响。这些实验发现，肝脏甘油三酯百分比响应于外部/内部环境而迅速变化。SLa的作用似乎不太明显，尽管它至少在某些繁殖条件下或在某些遗传背景下可能会增加肝脏甘油三酯的比例。本研究结果不排除SLa参与脂质代谢或其他生理过程的可能性。然而，我们认为，肤色调节是唯一确定的作用，SLa迄今为止证明在这个物种。
Somatolactin alpha (SLa) is a fish-specific peptide hormone secreted from the pituitary. In medaka, SLa functions to darken the skin color and lack of SLa makes it pale. Transcription of SLa is enhanced or suppressed when fish are kept in dark or bright conditions, respectively, indicating SLa’s important role in background acclimation of the skin color. Bizarrely, however, the lack of SLa seems to cause the additional defect of increased triglycerides in organs, which could not be rescued (decreased) by its overexpression. To assess this enigmatic result, we investigated genetic (the SLa, Slc45a2, r, and Y genes) and nongenetic (age, fasting, water temperature, and background color) effects on hepatic triglycerides. These experiments found that percent hepatic triglycerides quickly change in response to external/internal environments. Effects of SLa seemed to be much less obvious, although it may increase the proportion of hepatic triglycerides at least during certain breeding conditions or under certain genetic backgrounds. The present results do not exclude the possibility that SLa takes part in lipid metabolism or other physiological processes. However, we suggest that skin-color regulation is the only definite role of SLa so far demonstrated in this species.
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在Medaka中，单个次要性特征和交配偏好的双重控制。
影响因子：
5.4
作者：
Fukamachi S;Kinoshita M;Aizawa K;Oda S;Meyer A;Mitani H
通讯作者：
Mitani H
DOI：
10.1007/978-4-431-92691-7_11
发表时间：
2011-01-01
期刊：
MEDAKA: A MODEL FOR ORGANOGENESIS, HUMAN DISEASE, AND EVOLUTION
影响因子：
--
作者：
Fukamachi, Shoji
通讯作者：
Fukamachi, Shoji
DOI：
10.1002/jez.a.273
发表时间：
2006-05-01
影响因子：
2.8
作者：
Cánepa, MM;Pandolfi, M;Vissio, PG
通讯作者：
Vissio, PG
影响因子：
4.8
作者：
Fukada, H;Ozaki, Y;Dickhoff, WW
通讯作者：
Dickhoff, WW
影响因子：
3.5
作者：
Fukamachi, Shoji;Yada, Takashi;Kinoshita, Masato
通讯作者：
Kinoshita, Masato