Dual control by a single gene of secondary sexual characters and mating preferences in medaka.
Dual control by a single gene of secondary sexual characters and mating preferences in medaka.
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在Medaka中，单个次要性特征和交配偏好的双重控制。
DOI：
10.1186/1741-7007-7-64
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发表时间：
2009-09-29
期刊：
影响因子：
5.4
通讯作者：
Mitani H
中科院分区：
文献类型：
--
作者：
Fukamachi S;Kinoshita M;Aizawa K;Oda S;Meyer A;Mitani H
动物利用各种各样的策略来吸引繁殖伙伴。行为实验通常表明视觉线索在鱼类中发挥着重要作用，但其分子基础仍然几乎完全未知。对模型物种（例如斑马鱼和青鳉）的研究可以研究行为和进化生物学中的这一基本问题。通过使用几种不同体色的实验室品系进行择偶经验，我们成功地鉴定了一种对生殖伴侣明显没有吸引力的青鳉突变体（颜色干扰；ci）。这种不美观似乎是由于皮肤中橙色色素细胞（黄细胞）减少所致。 ci 品系的生长激素α (SLa) 基因携带突变，因此我们预计 SLa 的过度表达会使青鳉具有超强的吸引力。事实上，在 ci 和 SLa 转基因 (Actb-SLa:GFP) 青鳉之间的选择中检测到了极其强烈的交配偏好。然而有趣的是，这些菌株表现出相反的偏差。也就是说，突变体和转基因青鳉喜欢与自己品系的伴侣交配，类似于性隔离。这项研究强调了 SLa 作为鱼类中一种新型的择偶基因。此外，这些结果首次证明单个基因可以多效且和谐地改变第二性征和交配偏好。尽管理论模型长期以来一直表明染色体上连锁基因的联合进化，但基因调控区域的突变（即单个基因的打开/关闭）可能足以触发两个不同方向的“失控”过程，从而促进（同域）物种形成。
Animals utilize a wide variety of tactics to attract reproductive partners. Behavioral experiments often indicate an important role for visual cues in fish, but their molecular basis remains almost entirely unknown. Studies on model species (such as zebrafish and medaka) allow investigations into this fundamental question in behavioral and evolutionary biology. Through mate-choice experiences using several laboratory strains of various body colors, we successfully identified one medaka mutant (color interfere; ci) that is distinctly unattractive to reproductive partners. This unattractiveness seems to be due to reduced orange pigment cells (xanthophores) in the skin. The ci strain carries a mutation on the somatolactin alpha (SLa) gene, therefore we expected over-expression of SLa to make medaka hyper-attractive. Indeed, extremely strong mating preferences were detected in a choice between the ci and SLa-transgenic (Actb-SLa:GFP) medaka. Intriguingly, however, the strains showed opposite biases; that is, the mutant and transgenic medaka liked to mate with partners from their own strain, similar to becoming sexually isolated. This study spotlighted SLa as a novel mate-choice gene in fish. In addition, these results are the first demonstration of a single gene that can pleiotropically and harmoniously change both secondary sexual characters and mating preferences. Although theoretical models have long suggested joint evolution of linked genes on a chromosome, a mutation on a gene-regulatory region (that is, switching on/off of a single gene) might be sufficient to trigger two 'runaway' processes in different directions to promote (sympatric) speciation.
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影响因子：
9.8
作者：
Davison, A;Chiba, S;Clarke, B
通讯作者：
Clarke, B
影响因子：
1.9
作者：
Kinoshita, M
通讯作者：
Kinoshita, M
影响因子：
2.4
作者：
Fukamachi, S;Wakamatsu, Y;Mitani, H
通讯作者：
Mitani, H
影响因子：
4.4
作者：
Benedet, Susana;Bjornsson, Bjorn Thrandur;Andersson, Eva
通讯作者：
Andersson, Eva
影响因子：
3.3
作者：
Fukamachi, S;Yada, T;Mitani, H
通讯作者：
Mitani, H