The interplay between genetic and bioelectrical signaling permits a spatial regionalisation of membrane potentials in model multicellular ensembles.
The interplay between genetic and bioelectrical signaling permits a spatial regionalisation of membrane potentials in model multicellular ensembles.
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DOI：
10.1038/srep35201
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发表时间：
2016-10-12
影响因子：
4.6
通讯作者：
Mafe S
中科院分区：
文献类型：
--
作者：
Cervera J;Meseguer S;Mafe S
以单细胞为中心的方法强调离子通道是决定个体特性的特定蛋白质，而不考虑它们对多细胞结果的贡献。我们模拟了不可兴奋细胞中遗传和生物电信号之间的相互作用，从局部单细胞水平到远程多细胞集合。单细胞遗传调控是建立在平均场动力学方程基础上的，涉及到mRNA和蛋白质的浓度。假定转录速率因子依赖于细胞电位的绝对值，该绝对值由电压门控的细胞离子通道和细胞间缝隙连接决定。遗传信号和电信号之间的相互作用可能允许将单细胞状态转换为提供时空信息的多细胞状态。模型结果对生物过程有明显的影响：(I)生物电信号可以覆盖略有不同的遗传前模式；(Ii)由于相邻空间区域之间持续的遗传差异，最初处于相同电位的细胞集合可以经历电区域化；以及(Iii)正常细胞电平衡的变化可能引发遗传调控的重大变化。
The single cell-centred approach emphasises ion channels as specific proteins that determine individual properties, disregarding their contribution to multicellular outcomes. We simulate the interplay between genetic and bioelectrical signals in non-excitable cells from the local single-cell level to the long range multicellular ensemble. The single-cell genetic regulation is based on mean-field kinetic equations involving the mRNA and protein concentrations. The transcription rate factor is assumed to depend on the absolute value of the cell potential, which is dictated by the voltage-gated cell ion channels and the intercellular gap junctions. The interplay between genetic and electrical signals may allow translating single-cell states into multicellular states which provide spatio-temporal information. The model results have clear implications for biological processes: (i) bioelectric signals can override slightly different genetic pre-patterns; (ii) ensembles of cells initially at the same potential can undergo an electrical regionalisation because of persistent genetic differences between adjacent spatial regions; and (iii) shifts in the normal cell electrical balance could trigger significant changes in the genetic regulation.
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DOI：
10.1523/jneurosci.6216-11.2012
发表时间：
2012-03-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Curti S;Hoge G;Nagy JI;Pereda AE
通讯作者：
Pereda AE
影响因子：
5.6
作者：
Emmons-Bell M;Durant F;Hammelman J;Bessonov N;Volpert V;Morokuma J;Pinet K;Adams DS;Pietak A;Lobo D;Levin M
通讯作者：
Levin M
影响因子：
3.6
作者：
Adams, Dany S.;Levin, Michael
通讯作者：
Levin, Michael
影响因子：
4.6
作者：
Green, Jeremy B. A.;Sharpe, James
通讯作者：
Sharpe, James
影响因子：
64.5
作者：
Gomez-Ospina, Natalia;Tsuruta, Fuminori;Dolmetsch, Ricardo
通讯作者：
Dolmetsch, Ricardo