Reduced default mode network connectivity in treatment-resistant idiopathic generalized epilepsy.
Reduced default mode network connectivity in treatment-resistant idiopathic generalized epilepsy.
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DOI：
10.1111/epi.12057
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发表时间：
2013-03
期刊：
影响因子：
5.6
通讯作者：
Szaflarski JP
中科院分区：
文献类型：
--
作者：
Kay BP;DiFrancesco MW;Privitera MD;Gotman J;Holland SK;Szaflarski JP
特发性全身性癫痫（IGE）对治疗抵抗是常见的，但其神经元相关性尚未完全了解。因此，本研究的目的是检查静息状态默认模式网络（DMN）的功能连接与治疗抵抗性IGE患者。治疗抵抗定义为尽管使用了足够剂量的丙戊酸（丙戊酸盐，VPA），但癫痫持续发作。包括60例癫痫患者和38例健康对照者的数据，他们同时进行EEG和静息态fMRI（EEG/fMRI）。独立成分分析（伊卡）和二元回归被用来量化DMN连接。使用基于种子的体素相关性进行了验证性分析。有一个显着减少的DMN连接与治疗难治性癫痫患者相比，谁是治疗反应和健康对照患者。连接性与癫痫持续时间呈负相关。我们在IGE患者的大样本中的发现表明IGE中存在DMN连接性降低，并表明在难治性癫痫中连接性进一步降低。DMN连接性可用作治疗抗性的生物标志物。
Idiopathic generalized epilepsy (IGE) resistant to treatment is common, but its neuronal correlates are not entirely understood. Thus, the aim of this study was to examine resting-state default mode network (DMN) functional connectivity in patients with treatment-resistant IGE. Treatment-resistance was defined as continuing seizures despite an adequate dose of valproic acid (valproate, VPA). Data from 60 epilepsy patients and 38 healthy controls who underwent simultaneous EEG and resting-state fMRI were included (EEG/fMRI). Independent component analysis (ICA) and dual regression were used to quantify DMN connectivity. Confirmatory analysis using seed-based voxel correlation was performed. There was a significant reduction of DMN connectivity in patients with treatment-resistant epilepsy when compared to patients who were treatment-responsive and healthy controls. Connectivity was negatively correlated with duration of epilepsy. Our findings in this large sample of patients with IGE indicate the presence of reduced DMN connectivity in IGE and show that connectivity is further reduced in treatment-resistant epilepsy. DMN connectivity may be useful as a biomarker for treatment-resistance.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
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影响因子：
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作者：
DiFrancesco, Mark W.;Holland, Scott K.;Szaflarski, Jerzy P.
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10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
5.7
作者：
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