Cell numbers, cell ratios, and developmental plasticity in the rod pathway of the mouse retina.
Cell numbers, cell ratios, and developmental plasticity in the rod pathway of the mouse retina.
复制标题
小鼠视网膜的杆途径中的细胞数，细胞比和发育可塑性。
作者：
细胞命运的精确规范被认为可以确保在种群中产生正确数量的神经元。程序性细胞死亡可能是控制细胞数量的另一种机制，被认为可以改善特定物种突触前和突触后神经元的适当比例。在这里，我们考虑了小鼠视网膜杆状通路中三种不同神经元群的大小：杆状光感受器、杆状双极细胞和AII无突细胞。在28个不同品系的小鼠中，所有三种细胞类型的数量都存在很大差异。它们数量的变化是不相关的，因此杆状双极细胞与杆状双极细胞的比例，以及杆状双极细胞与所有无毛细胞的比例也会发生变化。在这些可变的突触前和突触后群体之间建立连接依赖于调节过程生长和形态分化的可塑性，我们通过实验对小鼠视网膜中杆状双极细胞和AII无突细胞进行了探索，每种细胞类型的数量都有所增加。虽然杆状双极树突和轴突树突以及AII小叶树突都可以根据局部同型细胞密度调节其面积大小，但AII无突细胞的树突附属物却没有。相反，这些过程表现出一种不同形式的可塑性，调节其重叠乔木的分支密度。在传入细胞和靶细胞数量的独立规范存在的情况下，每种形式的可塑性都应确保视网膜覆盖的均匀性。在一组不同的小鼠品系中，视网膜杆状通路的前三种细胞类型的数量存在很大差异。然而，这种差异是不相关的，这就导致了这些突触伙伴的比例发生了实质性的变化。形态分化过程中的可塑性确保了视网膜覆盖和连接的均匀性，但其机制可能有所不同，甚至在同一细胞产生的不同过程组之间也是如此。
The precise specification of cellular fate is thought to ensure the production of the correct number of neurons within a population. Programmed cell death may be an additional mechanism controlling cell number, believed to refine the proper ratio of pre‐ to post‐synaptic neurons for a given species. Here, we consider the size of three different neuronal populations in the rod pathway of the mouse retina: rod photoreceptors, rod bipolar cells, and AII amacrine cells. Across a collection of 28 different strains of mice, large variation in the numbers of all three cell types is present. The variation in their numbers is not correlated, so that the ratio of rods to rod bipolar cells, as well as rod bipolar cells to AII amacrine cells, varies as well. Establishing connectivity between such variable pre‐ and post‐synaptic populations relies upon plasticity that modulates process outgrowth and morphological differentiation, which we explore experimentally for both rod bipolar and AII amacrine cells in a mouse retina with elevated numbers of each cell type. While both rod bipolar dendritic and axonal arbors, along with AII lobular arbors, modulate their areal size in relation to local homotypic cell densities, the dendritic appendages of the AII amacrine cells do not. Rather, these processes exhibit a different form of plasticity, regulating the branching density of their overlapping arbors. Each form of plasticity should ensure uniformity in retinal coverage in the presence of the independent specification of afferent and target cell number. Across a panel of different mouse strains, there exists a large variation in the numbers of the first three cell types of the rod pathway of the retina. That variation is not correlated, however, yielding substantial variation in the ratios of these synaptic partners. Plasticity during morphological differentiation ensures uniformity of retinal coverage and connectivity, yet the mechanisms can vary, even between different sets of processes arising from the same cell.
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影响因子：
--
作者：
Edqvist, Per-Henrik D.;Lek, Madelen;Boije, Henrik;Lindback, Sarah M.;Hallbook, Finn
通讯作者：
Hallbook, Finn
影响因子：
2.5
作者：
Keeley, Patrick W.;Whitney, Irene E.;Reese, Benjamin E.
通讯作者：
Reese, Benjamin E.
影响因子：
1.9
作者：
Demb, Jonathan B.;Singer, Joshua H.
通讯作者：
Singer, Joshua H.
DOI：
10.1002/cne.25064
发表时间：
2021-06
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Camerino MJ;Engerbretson IJ;Fife PA;Reynolds NB;Berria MH;Doyle JR;Clemons MR;Gencarella MD;Borghuis BG;Fuerst PG
通讯作者：
Fuerst PG
影响因子：
5.3
作者：
Lee, Sammy C. S.;Cowgill, Erin J.;Reese, Benjamin E.
通讯作者：
Reese, Benjamin E.