Parental Longevity and 7-Year Changes in Blood Pressures in Adult Offspring
Parental Longevity and 7-Year Changes in Blood Pressures in Adult Offspring
复制标题
父母的寿命和成年后代七年的血压变化
DOI：
10.1161/01.hyp.0000173068.13787.4d
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发表时间：
2005
期刊：
影响因子：
8.3
通讯作者：
S. Hercberg
中科院分区：
文献类型：
--
作者：
M. Zureik;P. Galan;S. Bertrais;D. Courbon;S. Czernichow;J. Blacher;P. Ducimetiere;M. Safar;S. Hercberg
在这份报告中，我们根据父母的寿命检查了成年后代血压的横截面和7年纵向变化。一组无症状性心血管疾病的志愿者参加了补充维生素和抗氧剂(SUVIMAX)血管研究(平均年龄52.3岁；48.3%的女性)，在基线和7年后进行了检查。分别分析了父亲(n=994)和母亲(n=896)的长寿情况。在那些父亲在65岁时去世的受试者中，那些父亲在65岁前活着但在80岁前去世的受试者，以及那些父亲在80岁前活着的受试者中，高血压的患病率分别为34.9%、28.5%和20.2%(P<；0.001)。3组长寿父亲的平均收缩压分别为128.4(±16.0)、125.3(±14.2)、123.6(±14.4)mm Hg(P<；0.001)。在随访期间，3组长寿父亲的平均收缩压升幅分别为5.3(±17.0)、4.2(±14.0)、1.6(±13.2)mm Hg(P<；0.001)。在基线无高血压的受试者中，高血压发生率分别为26.6%、17.7%和15.3%(P<；0.009)。根据基线或心血管危险因素的变化调整后的多变量分析不会改变这些结果。相比之下，在横断面或纵向分析中，母亲的长寿与血压测量之间没有关系。这项研究表明，父亲的过早死亡与子代的收缩压加速进展和高血压的发生率更高有关。这些结果表明，在成年人中，父亲的长寿与血压之间存在着动态和连续的联系。
In this report, we examined the cross-sectional and the 7-year longitudinal changes in blood pressures in adult offspring according to parental longevity. A population of volunteers free of symptomatic cardiovascular diseases who participated to the Supplementation en Vitamines et en Minéraux Antioxydants (SUVIMAX) Vascular Study (mean age 52.3 years; 48.3% women) were examined at baseline and 7 years later. Paternal (n=994) and maternal (n=896) longevity were analyzed separately. The prevalence of hypertension at baseline in subjects whose father died at <65 years of age, in those whose fathers were alive by age 65 but died by 80 years of age, and in those whose fathers were alive by age 80 was respectively 34.9%, 28.5%, and 20.2% (P<0.001). The means of systolic blood pressure in the 3 groups of paternal longevity were respectively 128.4 (±16.0), 125.3 (±14.2), and 123.6 (±14.4) mm Hg (P<0.001). During the follow-up, the mean systolic blood pressure increases in the 3 groups of paternal longevity were respectively 5.3 (±17.0), 4.2 (±14.0), and 1.6 (±13.2) mm Hg (P<0.001). In subjects without hypertension at baseline, hypertension occurred during the follow-up in 26.6%, 17.7%, and 15.3% (P<0.009), respectively. Multivariate analyses adjusted for baseline or changes in cardiovascular risk factors did not modify these results. In contrast, there was no relationship between maternal longevity and blood pressure measurements in either cross-sectional or longitudinal analyses. This study suggests that paternal premature death was associated with accelerated progression of systolic blood pressure and higher occurrence of hypertension in offspring. These results indicate that there are dynamic and continuous processes linking paternal longevity to blood pressure in adults.
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DOI：
10.1093/gerona/58.5.m425
发表时间：
2003-05
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Dellara F. Terry;M. Wilcox;M. McCormick;Elizabeth V. Lawler;T. Perls
通讯作者：
Dellara F. Terry;M. Wilcox;M. McCormick;Elizabeth V. Lawler;T. Perls
男性双胞胎的中年心血管危险因素水平更高，25 年随访后的死亡率与其父母的寿命有关。
DOI：
10.1093/gerona/58.4.m367
发表时间：
2003
期刊：
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子：
--
作者：
Reed,Terry;Carmelli,Dorit;Robinson,TiffanyS;Rinehart,ShannonA;Williams,ChristopherJ
通讯作者：
Williams,ChristopherJ
影响因子：
--
作者：
Psaty, BM;Furberg, CD;Lumley, T
通讯作者：
Lumley, T
影响因子：
37.8
作者：
S. Franklin;William Gustin;N. Wong;M. Larson;M. Weber;W. Kannel;Daniel Levy
通讯作者：
S. Franklin;William Gustin;N. Wong;M. Larson;M. Weber;W. Kannel;Daniel Levy