Ensemble place codes in hippocampus: CA1, CA3, and dentate gyrus place cells have multiple place fields in large environments.
Ensemble place codes in hippocampus: CA1, CA3, and dentate gyrus place cells have multiple place fields in large environments.
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海马中的集合位置代码：CA1，CA3和Dentate Gyrus Plote细胞在大环境中具有多个位置。
DOI：
10.1371/journal.pone.0022349
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Fenton AA
中科院分区：
文献类型：
--
作者：
Park E;Dvorak D;Fenton AA
之前我们报道过，海马体位置代码必须是一个整体代码，因为海马体 CA1 区域的位置细胞在一个更自然、大于标准的外壳中具有多个位置字段，并且带有允许 3-D 移动的楼梯。在这里，我们通过表征大鼠在标准 76 cm 圆柱体和大于标准盒子 (1.8 m×1.4 m) 中觅食时 CA1、CA3 和齿状回 (DG) 海马分区中的位置细胞的空间放电特性，进一步研究了海马位置代码的性质，该盒子没有楼梯或任何允许 3-D 运动的内部结构。训练大鼠使用计算机控制的食物输送连续觅食 1 小时。我们确认大多数位置单元在标准圆柱体中具有单位置场，并且位置发射模式在圆柱体和大外壳之间重新映射。重要的是，CA1、CA3 和 DG 区域的位置细胞都具有多个不规则间隔的位置区域，正如我们之前针对 CA1 所报道的那样。我们得出的结论是，多个位置场是海马位置细胞的基本特征，它可以在足够小的空间内简化为单个区域。集合位置代码与这些观察结果兼容，这与任何专用编码方案相矛盾。
Previously we reported that the hippocampus place code must be an ensemble code because place cells in the CA1 region of hippocampus have multiple place fields in a more natural, larger-than-standard enclosure with stairs that permitted movements in 3-D. Here, we further investigated the nature of hippocampal place codes by characterizing the spatial firing properties of place cells in the CA1, CA3, and dentate gyrus (DG) hippocampal subdivisions as rats foraged in a standard 76-cm cylinder as well as a larger-than-standard box (1.8 m×1.4 m) that did not have stairs or any internal structure to permit movements in 3-D. The rats were trained to forage continuously for 1 hour using computer-controlled food delivery. We confirmed that most place cells have single place fields in the standard cylinder and that the positional firing pattern remapped between the cylinder and the large enclosure. Importantly, place cells in the CA1, CA3 and DG areas all characteristically had multiple place fields that were irregularly spaced, as we had reported previously for CA1. We conclude that multiple place fields are a fundamental characteristic of hippocampal place cells that simplifies to a single field in sufficiently small spaces. An ensemble place code is compatible with these observations, which contradict any dedicated coding scheme.
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DOI：
10.1523/jneurosci.2862-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
通讯作者：
Ludvig N
影响因子：
56.9
作者：
Fyhn, M;Molden, S;Moser, MB
通讯作者：
Moser, MB
影响因子：
3.5
作者：
Alme, C. B.;Buzzetti, R. A.;Barnes, C. A.
通讯作者：
Barnes, C. A.
影响因子：
1.9
作者：
Lever, C;Burgess, N;O'Keefe, J
通讯作者：
O'Keefe, J
影响因子：
64.8
作者：
Lee, I;Yoganarasimha, D;Knierim, JJ
通讯作者：
Knierim, JJ